期刊文献+

蛋白质组学技术在小儿外科疾病筛查中的应用

Proteomics technology application in screening of pediatric surgery diseases
原文传递
导出
摘要 蛋白质组学有助于在蛋白质水平了解疾病的发生、发展.利用蛋白质组学方法研究分析先天畸形疾病的发生、发展机制,对胚胎早期的诊断、预防和干预先天畸形的发生具有重要意义.该文重点阐述蛋白质组学的研究最新进展,综述其在小儿外科疾病筛查中的应用. Proteomics can explore the occurrence,development of diseases from the protein level.There is important significance for us to analyse the occurrence and development mechanism of the congenital malformation disease,the diagnosis of early embryo,prevention and intervention of birth defects of the occurrence of diseases using the method of proteomics research.This paper focuses on the latest progress in research of proteomics and its application in screening for congenital malformation diseases.
出处 《国际儿科学杂志》 2014年第2期149-152,共4页 International Journal of Pediatrics
基金 国家自然科学基金资助项目(81270436)
关键词 先天畸形 蛋白质组学 儿童 疾病 Congenital malformations Proteomics Children Disease
  • 相关文献

参考文献31

  • 1中华人民共和国卫生部,中国残疾人联合会.中国提高出生人口素质、减少出生缺陷和残疾行动计划(2002~2010年)[J].中国生育健康杂志,2002(3):98-101. 被引量:60
  • 2Ideker T, Thorsson V, Ranish JA, et al. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network.Science,2001,292 (5518 ) :929-934.
  • 3Gerlal R. Phenomics:fiction or the future. Trends Neurosci, 2002,25 (10) :506-509.
  • 4Petrieoin EF, Zoon KC, Kohn EC, et al. Clinical proteomics: transla- ting benchside promise into bedside reality. Nature Rev Drug Discov, 2002,1 (9) :683-695.
  • 5O Farrel PH. High resolution two-dimensional electrophoresis of proteins. J Biol Chern, 1975,250 ( 10 ) :4007 -4021.
  • 6Gorg A, Obermaier C, Boguth G, et al. The current state of two-di- mensional electrophoresis with immobilized PH gradients. Electro- phoresis ,2000,21 ( 1 ) :1037-1053.
  • 7Abbott A. A post-genomic challenge:learning to read patterns of protein synthesis. Nature, 1999,402 ( 6763 ) : 715-720.
  • 8Boguski MS, Melntosh MW. Biomedical informatics for proteomics. Nature, 2003,422 ( 6928 ) : 233 -237.
  • 9Govorun VM, Archakov AI. Proteomic technologies in modem biomedical science. Biochemistry ( Mosc ), 2002, 67 ( 10 ) : 1109- 1123.
  • 10Kodadek T. Protein microarrays Biol,2001,8(2) :105-115.

二级参考文献85

共引文献94

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部