摘要
阿尔茨海默病(AD)是老年人最常见的神经退行性疾病。微管相关蛋白tau的改变与AD发病和进展密切相关。以tau蛋白为靶标进行AD防治药物研究已成为近年AD研究领域的一大热点,主要包括抑制tau蛋白磷酸化、聚集,加速tau蛋白解聚。本文对以tau蛋白为靶标的AD防治药物研究的现状进行综述。
Alzheimer＆#39;s disease （AD） is the general neurodegenerative disease in the elderly. Alterations of microtubule associated pro-tein tau are closely related to the onset and progression of AD. The role of tau protein in the development of AD has been a focus in the cur-rent study of AD, with an emphasis on the identification of compounds that inhibit tau protein phosphorylation and aggregate, and accelerate tau protein depolymerization. The current research status of tau protein as target of AD preventive and therapeutic drug was also reviewed.
出处
《中国康复理论与实践》
CSCD
北大核心
2014年第3期240-244,共5页
Chinese Journal of Rehabilitation Theory and Practice
基金
国家自然科学基金项目(No.81274120)
北京市自然科学基金项目(No.7132110)
北京市新世纪百千万人才工程项目(No.008-0014)
北京市高层次卫生人才工程项目(No.2009-3-66)
教育部留学回国人员科研启动基金项目(第45批)
关键词
阿尔茨海默病
神经纤维缠结
药物
综述
Alzheimer＇s disease
neurofibrillary tangles
microtubule associated protein tau
drug
review
