摘要
目的 探讨细胞角蛋白19（CYFRA21-1）、血清癌胚抗原（CEA）与恶性肿瘤特异性生长因子（TSGF）联合检测对早期诊断肺炎的临床应用价值.方法 选择2009年7月～2012年7月温岭市妇幼保健院儿科住院部收治的193例肺炎患者作为研究对象[按肺炎类型分为细菌性肺炎组（78例）、病毒性肺炎组（53例）、支原体肺炎组（62例）],选择在温岭市妇幼保健院幼儿园入园体检的健康幼儿50名作为对照组.采用酶偶联吸附免疫分析法对细菌、病毒、支原体感染的婴幼儿肺炎患儿及正常幼儿进行血清CEA、CYFRA21-1、TSGF检测,分析三者联合检测在诊断和鉴别肺炎中的作用.结果 细菌性肺炎组、病毒性肺炎组、支原体肺炎组血清CEA[（5.51±2.13）、（4.05±1.75）、（6.69±2.91）ng/mL]、CYFRA21-1 [（9.41 ±4.95）、（6.33±2.49）、（5.74±1.13）ng/mL]、TSGF[（67.48±14.49）、（88.46±21.36）、（74.52±19.37）ng/mL]水平均显著高于对照组[CEA：（0.7 1±0.04）ng/mL;CYFRA21-1：（0.81±0.07）ng/mL;TSGF：（13.41±4.77）ng/mL],差异有统计学意义（P＜0.05）;其中支原体肺炎组血清CEA含量最高,细菌性肺炎组血清CYFRA21-1含量最高,病毒性肺炎组血清TSGF含量最高.在支原体肺炎组中,CEA阳性检出率（91.94％）较高,CYFRA21-1在细菌性肺炎组阳性检出率（97.44％）最高,病毒性肺炎组中TSGF阳性检出率（96.23％）最高.三者联合检测后敏感性和阴性预测值明显升高,与单检CEA和单检CYFRA21-1相比,差异有统计学意义（P＜0.05）.结论 血清CEA、CYFRA21-1、TSGF检测可以作为肺炎初步诊断的指标之一.
Objective To explore the clinical application value of CYFRA21-1,CEA and TSGF combined detection in early diagnosis of infant pneumonia.Methods From July 2009 to July 2012,193 pneumonia children treated in Maternal and Child Health Hospital of Wenling City were selected,according to the kind of pneumonia,78 cases were in bacteria pneumonia group; 53 cases were in viral pneumonia group; 62 cases were in mycoplasma pneumonia group.And at the same time,50 normal children in the kindergarten of Maternal and Child Health Hospital of Wenling City were as the control group.The enzyme immunoassay coupling adsorption was used for detecting the serum CEA,CYFRA21-1,TSGF of bacteria,virus,mycoplasma pneumonia children and normal children.Then,the effect of the 3-combined detection in diagnosis and differential diagnosis of pneumonia were analyzed.Results The bacteria pneumonia group,viral pneumonia group and mycoplasma pneumonia group,the serum CEA levels [（5.51±2.13）,（4.05±1.75）,（6.69±2.91） ng/mL],CYFRA21-1 levels [（9.41±4.95）,（6.33±2.49）,（5.74±1.13） ng/mL],TSGF levels [（67.48±14.49）,（88.46±21.36）,（74.52±19.37） ng/mL] were significantly higher than those of the control group [CEA：（0.71±0.04） ng/mL,CYFRA21-1 （0.81±0.07） ng/mL,TSGF：（13.41±4.77） ng/mL],the differences were statistically significant （P ＜ 0.05）;the content of serum CEA of children with mycoplasma pneumonia was the highest; the content of serum CYFRA21-1 of children with bacterial pneumonia was the highest; the content of serum TSGF of children with viral pneumonia was the highest.In mycoplasma pneumonia,the positive rate of CEA was higher （91.94％）; in bacterial pneumonia,the positive rate of CYFRA21-1 was the highest （97.44％）; in viral pneumonia,the positive rate of TSGF was the highest （96.23％）.The sensitivity and negative predictive value of 3-combined detection were significantly increased,compared with the single CEA or CYFRA21-1,the differences were statistically significant （P ＜ 0.05）.Conclusion The serum CEA,CYFRA21-1,TSGF detection can be used as the indexes of initial diagnosis of pneumonia.
出处
《中国医药导报》
CAS
2014年第9期62-64,67,共4页
China Medical Herald
基金
国家自然科学基金(编号30971310)
