摘要
目的:系统评价苦瓜提取物对Ⅱ型糖尿病小鼠血糖的影响。方法:计算机检索中文期刊数据库、维普中文科技期刊数据库、万方数据库收录的1979年1月至2012年12月发表的关于苦瓜提取物影响Ⅱ型糖尿病小鼠空腹血糖的相关研究,并辅以手工检索,对照纳入标准筛选文献。对符合纳入标准的研究的质量进行评价,用RevMan5.2软件进行Meta分析。结果:共收集到相关文献23篇,其中符合纳入标准的有14篇,Meta分析结果显示,异质性检测I2=5%,合并结果Z=11.38(P<0.00001),有统计学意义,小鼠空腹血糖合并效应值采用标准化均数差(SMD),SMD=1.72,95%CI(1.43,2.02)。结论:苦瓜提取物能够降低Ⅱ型糖尿病模型小鼠空腹血糖值。
Objective： To systematically review the influence of bitter melon extract on blood glucose in mice with type Ⅱ diabetes. Methods： The literatures related to effects of bitter melon extract on blood glucose in mice with type Ⅱ diabetes from January 1979 to December 2012 were collected by the computer, from search of CNKI, VIP and Wan-fang databases combined with manual search. Those qualified studies according to inclusion criteria received quality evaluation and Meta- analysis by Rev Man 5.2 software. Results： The 23 literatures were collected and 14 studies were included among them. Meta-analysis shows /2--5% in heterogeneity testing; the combined result is Z=11.38 （P〈0.00001）, with statistically significance. Combined effect values of blood glucose in mice with the standardized mean differences （SMD）, SMD=l.72, 95%CI （1.43, 2.02）. Conclusion： Bitter melon extract can decrease blood glucose values in mice with type Ⅱ diabetes.
出处
《中医药导报》
2014年第3期128-130,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
2011中医养生学重点实验室开放课题(2011-JYBZZ-SYSKF002)
关键词
苦瓜提取物
糖尿病小鼠
血糖
META分析
Bitter melon extract
Mice with type Ⅱ diabetes
Blood glucose
Meta-analysis
