摘要
目的:探讨阿德福韦酯在临床使用中致低血磷性骨软化症的规律及特点,为临床安全用药提供依据。方法:以"阿德福韦酯"、"低血磷"、"骨软化症"、"范可尼综合征"为关键词,检索近6年(2008—2013年)中国期刊全文数据库、万方数据库、PubMed、HighWire数据库,共收录相关文献28篇,共计46例病例,对46例病例进行回顾性分析。结果:长期低剂量(10 mg/d)使用阿德福韦酯可引起低血磷性骨软化症。结论:应加强阿德福韦酯的不良反应监测,特别是监测其引起骨软化症的严重不良反应,以保证患者用药安全。
OBJECTIVE：To study the regularities and characteristics of adefovir dipivoxil-induced hypophosphatemia osteomalacia for clinical reference of safe use of drugs.METHODS：By retrieving Chinese Journal Full-text Database,Wanfang database,PubMed,HighWire database during 2008-2013 with the key words-＂adfovir dipivoxil＂,＂hypophosphatemia＂,＂osteomalacia＂ and ＂Fanconi syndrome＂,a total of 28 papers （46 cases） were collected and which were analyzed retrospectively.RESULTS：Long term use of adefovir dipivoxil in low-dose （10 mg/d） might cause hypophosphatemia osteomalacia.CONCLUSION：It is important to strengthen monitoring on the adverse drug reactions induced by Adefovir dipivoxil,especially the hypophosphatemia osteomalacia induced by which to ensure patients＇ medication safety.
出处
《中国医院用药评价与分析》
2014年第2期162-165,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
阿德福韦酯
低血磷
骨软化症
范可尼综合征
回顾性分析
Adefovir dipivoxil
Hypophosphatemia
Osteomalacia
Fanconi syndrome
Retrospective analysis
