摘要
目的:探讨脑胶质瘤术后调强放疗中采用同步加量技术的剂量学特点。方法:选取15例进行放射治疗的脑胶质瘤术后患者分别进行序贯加量和同步加量的调强放疗计划设计,利用剂量体积直方图评价两种技术对靶区和正常组织的照射剂量。计划靶区PTV-A、PTV-G的处方剂量分别为50 Gy和60 Gy。结果:与序贯加量相比同步加量技术能减少对靶区PTV-A的额外照射,使其实际受量更接近理想的处方剂量要求,同时正常脑组织的平均剂量降低17.4%(P=0.003),V10、V20、V30和V40分别减少14.8%、22.8%、25.2%和23.4%(P<0.05,对所有的比较)。结论:在脑胶质瘤术后放疗中同步加量技术比序贯加量技术更能保护肿瘤周围的正常脑组织,同时减少了治疗时间。
Objective： To investigate dosimetric characteristics of simultaneous integrated boost technique in intensity-modulat ed radiotherapy for glioma. Methods： Fifteen patients with brain glioma were enrolled in this study. Sequential Boost and Si multaneous Integrated Boost plan were performed for each patient. The dose distributions of target volume and normal tissues were analyzed using the dose-volume histogram （DVH）. The prescription doses for PTV-A and PTV-G were 50 Gy and 60 Gy respectively. Results： The Simultaneous Integrated Boost plan reduced additional irradiation for PTV-A compared with sequen- tial boost plan. The actual received dose of PTV-A was more close to the prescription dose. The average dose of normal brain tissue is reduced by 17.4%, while V10, V20, V30 and V40 were reduced 14.8%, 22.8%, 25.2% and 23.4% respectively （P〈0.05, for all comparisons）. Conclusions： Compared with sequential boost technique, the simultaneous integrated boost technique can better protect the normal brain tissue surrounding the tumor and reduce the treatment time.
出处
《中国医学物理学杂志》
CSCD
2014年第2期4727-4729,4759,共4页
Chinese Journal of Medical Physics
基金
国家自然科学基金资助项目(81172128
81372411)
关键词
脑胶质瘤
调强放射治疗
同步加量
剂量学
brain glioma
intensity-modulated radiotherapy
simultaneous integrated boost
dosimetry
