摘要
目的:利用实时超声弹性成像(Real-time elastography,RTE)观察离体及活体肝脏射频消融(Radiofrequency ablation,RFA)术后消融灶的弹性变化,探讨RTE评估RFA消融范围的价值。方法:离体实验选取新鲜离体猪肝5个,活体实验选取新西兰大白兔20只。在超声引导下将射频针置于猪肝及兔肝内进行消融,分别得到消融灶20个。RFA结束后采用RTE观察消融灶,测量消融灶最大切面的左右径及前后径并计算面积,与大体标本测量值进行比较。结果:消融结束后RTE图像显示离体猪肝及活体兔肝消融灶呈均匀蓝色,与周围组织分界清楚。Pearson相关分析显示离体猪肝RFA术后RTE测量消融灶面积与大体标本测量结果呈显著相关(r=0.91,P<0.05),Spearman相关分析显示活体兔肝RFA术后RTE测量消融灶面积与大体标本测量结果亦具有较好的相关性(r=0.49,P<0.05)。结论:RTE可清晰显示肝脏RFA灶的范围,有望成为评价RFA的有效方法。
Objective： To investigate the elasticity change of ablative lesions resulting from radiofrequency ablation（RFA） in vitro liver and in vivo liver by real-time elastography （RTE）, evaluate RTE in depicting circumscription of ablative lesions. Materials and Methods： Five in vitro porcine livers and twenty rabbits livers were chosen for this study. Twenty ablative lesions were obtained using RFA under ultrasound guidance in each experiment. After RFA, RTE was performed. The maximum vertical diameter and transverse diameter of ablative lesions were taken on RTE image and compared with the obtained from pathologic examination. Results： Homogeneous blue and distinct circumscription from liver tissue was showed on RTE image of all ablative lesions performed RFA in experiments. Pearson correlation analysis demonstrated that the area of ablative lesions measured on RTE image performed after RFA correlated well with the measurement on macropathology specimen（r=0.91, P〈0.05） in vitro liver experment. And Spearman correlation analysis demonstrated that the area of ablative lesions measured on RTE image performed after RFA correlated well with the measurement on macropathology correlated （r=0.49, P〈 0.05） in vivo liver experment. Conclusions： RTE may be reliable for depicting the circumscription of the RFA lesions. RTE may be the effective method for evaluating RFA lesions.
出处
《中国临床医学影像杂志》
CAS
2014年第3期176-178,共3页
Journal of China Clinic Medical Imaging
基金
国家自然科学基金项目(No.81060202)
广西壮族自治区卫生厅自筹基金项目(No.Z2010368)
高等学校博士学科点专项科研基金项目(No.20104503120003)
关键词
肝
兔
猪
导管消融术
超声检查
Liver
Rabbits
Swine
Catheter ablation
Uhrasonography
