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非瓣膜性心房颤动患者红细胞分布宽度与CHADS2、CHA2DS2-VASc评分的关系 被引量：5

The relationship of red blood cell distribution width and CHADS2/ CHA2DS2-VASc Score in non valvular atrial fibrillation patients
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摘要 目的：探讨非瓣膜性心房颤动（房颤）患者红细胞分布宽度（RDW）与评估房颤患者发生血栓栓塞风险的CHADS2和CHA2DS2-VASc评分的关系。方法：连续入选非瓣膜性房颤患者99例（其中阵发房颤68例，持续房颤31例），每例患者均进行CHADS2和CHA2DS2-VAsc评分，同时记录年龄、性别、伴发疾病、实验室指标及超声心动图结果。根据CHADS2及CHA2DS2-VASc评分将房颤患者发生血栓栓塞的风险分为低中危组和高危组，比较房颇患者发生血栓栓塞风险的低中危组与高危组各项指标的差异，同时探讨房颤患者RDW与CHADS2、CHA2DS2-VASc评分的关系。结果：无论何种分组方式，两组间年龄、高血压史、糖尿病史、冠心病史、脑卒中史有统计学差异（P〈0．05）。与低中危组相比，高危组患者年龄增加，RDW、血肌酐升高，左房直径增加，左室射血分数下降（P〈0．05）。多变量Logistic回归分析显示，RDW是房颤患者CHADS2、CHA2DS2-VASc评分的独立预测因素（OR值分别是2．184、3．815，均P〈0．05）。预测CHADS2高分的RDW的ROC曲线下面积为0．690（95％CI：0．583-0．797，P〈0．05），预测CHA2DS2-VASc高分的RDw的ROC曲线下面积为0．735（95％CI：0．634-0．836，P〈O．05）。结论：非瓣膜性房颇患者RDW与CHADS2和CHA2DS2-VASc评分呈正相关，而且是CHADS2、CHA2DS2-VASc评分的独立预测因素。 Objective： To investigate the relationship between red blood cell distribution width （RDW） and CHADS2, CHA2DS2-VASc score used for the evaluation of thromboembolism risk in patients with non-valvular atrial fibrillation （Af）. Method： Our study included 99 patients with Af （68 with paroxysmal Af and 31 with persistent Af）. We calculated CHADS2 and CHA2DS2-VASc risk score for each patient and recorded sex, age, comorbidities, laboratory parameters, and echocardiography. According to CHADS2 and CHA2DS2-VASc scores, we divided the Af patients into low-intermediate risk group and high risk group respectively, then compared the parameters between the two groups, and evaluated the relationship between RDW and CHADS2/CHA2DS2-VASc score in patients with Af. Result. The base characteristics between two groups had significant difference in sex, age, comorbidities, no matter using which kind of grouping method. High CHADS2, CHA2DS2-VASc score group had older age, higher RDW, creatinine, left atrial diameter and lower left ventricular ejection fraction, when compared to the low CHADS2, CHA2DS2-VASc score group. The multivariate logistic regression analysis was performed to predict high CHADS2, CHA2DS2-VASc scores. The results revealed that RDW was an independent predictor （OR： 2. 184, 3. 825, P〈0. 05）. The area under the receiver-operating characteristic curve of RDW was 0. 690 （95%CI： 0. 583-0. 797, P〈0. 05） to predict high CHADS2 score and 0. 735 （95%CI： 0. 634-0. 836, P〈0.05） to predict high CHA2DS2-VASc score. Conclusion： RDW is significantly correlated with CHADS2 and CHA2DS2-VASc score in patients with Af, as well as an independent predictor of high CHADS2 and CHA2DS2- VASc score.
作者 刘洪梅 邵清淼 缪帅 许纲 袁如玉 李广平 刘彤
机构地区 天津医科大学第二医院心脏科
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2014年第3期207-210,共4页 Journal of Clinical Cardiology
关键词 心房颤动 红细胞分布宽度 CHADS2 CHA2DS2-VASc atrial fibrillation red blood cell distribution width CHADS2 CHA2DS2-VASc
分类号 R541.7 [医药卫生—心血管疾病]
  • 相关文献

参考文献11

  • 1WOLF P A, BENJAMIN E J, BELANGER A J, et al. Secular trends in the prevalence of atrial fibrilla- tion: The Framingham Study[J]. Am Heart J,1996, 131:790--795.
  • 2CAMM A J, KIRCHHOF P, LIP G Y, et al. Guide- lines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)[J]. Eur Heart J, 2010,31 : 2369-- 2429.
  • 3FELKER G M, ALLEN L A, POCOCK S J, et al. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Pro- gram and the Duke Databank[J]. J Am Coil Cardiol, 2007,50:40--47.
  • 4MONTAGNANA M, CERVELLIN G, MESCHI T, et al. The role of red blood cell distribution width in cardiovascular and thrombotic disorders [J]. Clin Chem Lab Med,2012,50:635--641.
  • 5TONELLI M, SACKS F, ARNOLD M, et al. Rela- tion between red blood cell distribution width and car- diovascular event rate in people with coronary disease[J]. Circulation, 2008,117 : 163-- 168.
  • 6CHAMBERLAIN A M, AGARWAL S K, FOLSOM A R, et al. A clinical risk score for atrial fibrillation in a biracial prospective cohort (from the Atheroscle- rosis Risk in Communities [ARIC] study)[J]. Am J Cardiol, 2011,107 : 85 -- 91.
  • 7SCHNABEL R B, SULLIVAN L M, LEVY D, et al. Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based co- hort study[J]. Lancet, 2009,373 : 739-- 745.
  • 8ANI C, OVBIAGELE B. Elevated red blood cell dis- tribution width predicts mortality in persons with known stroke[J]. J Neurol Sci, 2009,277 : 103-- 108.
  • 9PATEL K V, FERRUCCI L, ERSHLER W B, et al. Red blood cell distribution width and the risk of death in middle-aged and older adults[J]. Arch Intern Med, 2009,169 : 515-- 523.
  • 10PERLSTEIN T S, WEUVE J, PFEFFER M A, et al. Red blood cell distribution width and mortality risk in a community-based prospective cohort [J]. Arch Intern Med, 2009,169 : 588-- 594.

二级参考文献11

  • 1刘彤,李广平.心房颤动的抗炎治疗[J].中华老年医学杂志,2007,26(8):634-636. 被引量：5
  • 2Liu T, Li L, Korantzopoulos P, et al. Meta-analysis of association between C-reactive protein and immediate success of electrical car- dioversion in persistent atrial fibrillation[J]. Am J Cardiol,2008,101 (12):1749-1752.
  • 3Felker GM, Allen LA, Pocock SJ, et al. Red cell distribution width as a novel prognostic marker in heart failure: Data from the CHARM program and the duke databank[J]. J Am Coil Cardiol,2007, 50(1):40-47.
  • 4Zhang ZY, Bian LQ, Kim SJ, et al. Inverse relation of total serum bil- irubin to coronary artery calcification score detected by multidetec- tor computed tomography in males[J].Clin Cardiol, 2012,35(5): 301-306.
  • 5Kalay N, Aytekin M, Kaya MG, et al. The relationship between in- flammation and slow coronary flow: increased red cell distribution width and serum uric acid levels[J].Turk Kardiyol Dern Ars, 2011, 39(6):463-468.
  • 6Letsas KP, Korantzopoulos P, Filippatos GS, et al. Uric acid eleva- tion in atrial fibrillation[J].Hellenic J Cardiol, 2010,51 (3): 209-213.
  • 7Yu K, Kim C, Sung E, et al. Association of serum total bilirubin with serum high sensitivity C-reactive protein in middle-aged men[J]. Korean J Fam Med, 2011,32(6):327-333.
  • 8Troughton JA, Woodside JV, Young IS, et al. Bilirubin and coronaryheart disease risk in the Prospective Epidemiological Study of Myo- cardial Infarction (PRIME) [J]. Eur J Cardiovasc Prey Rehabil, 2007,14(1):79-84.
  • 9Celik A, Koc F, Kadi H, et al. Relationship between red cell distri- bution width and echo cardiographic parameters in patients with di- astolic heart failure[J]. Kaohsiung J Med Sci, 2012,28(3):165-172.
  • 10Forhecz Z, Gombos T, Borgulya G, et al. Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state[J]. Am Heart J, 2009, 158(4):659-666.

共引文献4

同被引文献49

  • 1周自强,胡大一,陈捷,张仁汉,李奎宝,赵秀丽.中国心房颤动现状的流行病学研究[J].中华内科杂志,2004,43(7):491-494. 被引量：1408
  • 2Fan, JG,Li, F,Cai, XB,Peng, YD,Ao, QH,Gao, Y.Effects of nonalcoholic fatty liver disease on the development of metabolic disorders[J].中国生物学文摘,2007,21(11):21-22. 被引量：52
  • 3Montagnana M,Cervellin G,Meschi T,et al.The role of red blood cell distribution width in cardiovascular and thrombotic disorders[J].Clin Chem Lab Med,2012,50(4):635-641.
  • 4Omair Y,Bibhu D,Seth S,et al.High-sensitivity C reactive protein and cardiovascular disease:a resolute belief or an elusive link[J].J Am Coll Cardiol,2013,62(5):397-408.
  • 5Llombart V,Garcia-Berrocoso T,Bustamante A,et al.Cardioembolic stroke diagnosis using blood biomarkers[J].Curr Cardiol Rev,2013,9(4):340-352.
  • 6Cushman M,Judd SE,Howard VJ,et al.N-terminal pro-B-type natriuretic peptide and stroke risk:the reasons for geographic and racial differences in stroke cohort[J].Stroke,2014,45(6):1646-1650.
  • 7Rosenberg MA,Maziarz M,Tan AY,et al.Circulating fibrosis biomarkers and risk of atrial fibrillation:The Cardiovascular Health Study(CHS)[J].Am Heart J,2014,167(5):723-728.
  • 8January CT,Wann LS,Alpert JS,et al.2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation[J].J Am Coll Cardiol,2014,64(21):e1-e76.
  • 9Hu YF,Chen YJ,Lin YJ,et al.Inflammation and the pathogenesis of atrial fibrillation[J].Nat Rev Cardiol,2015,12(1):1-14.
  • 10Montagnana M,Cervellin G,Meschi T,et al.The role of red blood cell distribution width in cardiovascular and thrombotic disorders[J].Clin Chem Lab Med,2011,50(4):635-641.

引证文献5

二级引证文献34

临床心血管病杂志
2014年 第3期

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