摘要
目的探讨降钙素原(PCT)、白细胞介素-6(IL-6)及C反应蛋白(CRP)对新生儿宫内细菌感染的诊断价值。方法选取2010—2011年在我院产科分娩、有宫内感染高危因素的新生儿,根据感染结局分为感染组及无感染组,检测两组新生儿脐血PCT、IL-6及CRP,比较两组新生儿脐血炎症指标的阳性率及各指标对宫内感染诊断的敏感度和特异度。结果共有195例新生儿纳入研究,其中感染组24例,无感染组171例。感染组脐血PCT与IL-6的阳性率均明显高于CRP,诊断细菌感染的敏感度及特异度分别为:PCT敏感度70.8%,特异度94.2%;IL-6敏感度79.2%,特异度89.5%;CRP敏感度33.3%,特异度96.5%。PCT与IL-6结合诊断感染的敏感度为95.8%。结论脐血PCT可作为宫内细菌感染早期诊断的有效指标,而PCT与IL-6结合可进一步提高诊断的敏感度,指导临床抗生素使用。
Objective To evaluate the value of cord blood procalcitonin （PCT）, interleukin-6 IL-6） and C reactive protein （CRP） in the diagnosis of intrauterine infections in newborn infants. Methods Total of 195 newborn infants were divided into two groups：infection group and non-infection group. Cord blood PCT, IL-6 and CRP were measured, and analyzed for sensitivity, specificity. Results The rates of elevated PCT and IL-6 were greater than the rate of elevated CRP in the infection group. The sensitivity and specificity were respectively 70.8% , 94. 2% for PCT, 33.3%, 96.5% for CRP and 79.2%, 89.5% for IL-6. The combination of PCT and IL-6 had a higher sensitivity of 95.8%. Conclusions Umbilical cord blood PCT is a useful remark of intrauterine bacterial infection in newborn infants. The combination of PCT and IL-6 has a antibiotics administration. higher sensitivity, and can be used as a marker for
出处
《中国新生儿科杂志》
CAS
2014年第2期98-101,共4页
Chinese Journal of Neonatology
