摘要
目的:探讨血清C反应蛋白(SCRP)与2型糖尿病患者胰高血糖素的关系。方法:选取2型糖尿病患者168例,按SCRP水平分为两组:A组:SCRP正常范围者(0<SCRP≤3 mg/L)82例;B组:SCRP升高者(3<SCRP≤17.2 mg/L)86例。收集所有患者一般临床资料,对两组的一般临床资料进行统计学分析。结果:(1)B组空腹、30 min、120 min胰高血糖素水平均高于A组(P<0.01或P<0.05)。(2)Pearson相关分析显示SCRP与空腹、30 min、120 min胰高血糖素,胰岛素抵抗指数(HOMA-IR)及甘油三酯(TG)均呈正相关(P<0.01或P<0.05)。(3)多元逐步回归分析显示SCRP、HOMA-IR是影响空腹胰高血糖素的独立相关因素(P<0.05),SCRP是影响30 min、120 min胰高血糖素水平的独立相关因素(P<0.01)。结论:2型糖尿病患者多时相胰高血糖素水平与SCRP有关。此外,空腹胰高血糖素水平与HOMA-IR有关。
Objective：To investigate the relationship between the levels of serum c-reactive protein（SCRP）and glucagon in patients with type 2 diabetes. Method：A total of 168 type 2 diabetic patients were divided into two groups according to their SCRP levels. Group A：82 patients with normal levels of SCRP（0-3 mg/L）;Group B：86 patients with elevated levels of SCRP（3-17.2 mg/L）.The general clinical date of all patients were collected and statistically analyzed between the two groups. Result：（1）The glucagons levels of fasting,30 minutes and 120 minutes after the oral glucose load in group A were higher than the group B（P＆lt;0.01 or P＆lt;0.05）.（2）Pearson correlation analysis showed that SCRP had a positive correlation with fasting,30 minutes,120 minutes glucagons,indexes of insulin resistance（HOMA-IR） and triglycerides（TG）（P＆lt;0.01 or P＆lt;0.05）.（3）Multiple stepwise regression analysis showed that SCRP,HOMA-IR were independent related factors of fasting glucacon（P＆lt;0.05）and SCRP was independent related factors of 30 minutes, 120 minutes glucacon（P＆lt;0.01）. Conclusion：The glucagon levels in different phases are associated with SCRP in type 2 diabetic patients. In addition,fasting glucagon levels is associated with HOMA-IR.
出处
《中国医学创新》
CAS
2014年第7期92-94,共3页
Medical Innovation of China
