摘要
目的 :研究糖皮质激素在交感神经系统和心血管活动调节中的作用。方法 :细胞外记录头端延髓腹外侧区 (RVL M)功能性质明确的前交感神经元自发放电 ;静脉注射皮质酮 (5 0、10 0、15 0μg/ kg)观察前交感神经元放电频率的变化。 结果 :静脉注射不同剂量皮质酮后 ,12个 RVL M前交感神经元的放电频率均较注射前明显增加 (P<0 .0 5 ) ,具有剂量依赖性 ,作用潜伏期为 (10 4± 2 5 ) s。 结论 :皮质酮能快速兴奋 RVL M前交感神经元 ,提示糖皮质激素可能通过“快速膜效应”
Objective: To study the role of glucocorticoid in the integration of sympathetic nervous system and cardiovascular activity. Methods: Neurons in the rostral ventrolateral medulla (RVLM) were extracelluarly recorded and identified as the presympathetic neurons of adult rats. The spontaneous discharge of the presympathetic neurons in the RVLM were observed by bolus intravenous injection of corticosterone (50, 100, 150 μg/kg). Results: The firing rate of 12 presympathetic neurons was increased by intravenous application of corticosterone ( P <0.05), and this effect showed a dose dependent manner. The latency of excitatory effect was (104±25) s. Conclusion: Corticosterone can rapidly excite the presympathetic neurons in the RVLM, this action might be involved in the integration of sympathetic nervous system through the “rapid membrane effects”.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2001年第1期24-27,共4页
Academic Journal of Second Military Medical University
基金
国家"973"计划资助项目!(G2 0 0 0 0 5 6 90 5)
军队"九五"医药科研基金资助项目! (96 M0 72 )
关键词
皮质酮
延髓
交感神经系统
细胞外记录
corticosterone
medulla oblongata
sympathetic nervous system
extracelluar recording
