摘要
目的:探讨C-erbB-2及nm23在侵袭性(即浸润性)乳腺癌组织中表达的预后意义。方法:应用免疫组化法对72例侵袭性乳腺癌组织进行C-erbB-2及nm23产物的检测。结果:癌组织中C-erbB-2及nm23的阳性率分别为50%,33.3%。C-erbB-2的表达与肿瘤大小及腋淋巴结转移呈正相关,而与病人术后生存年限负相关。nm23的表达在淋巴结无转移组明显高于有转移组,并与患者的术后生存年限正相关,与C-erbB-2的表达负相关,但与肿瘤大小无关。C-erbB-2及nm23的表达均与乳癌病理类型无关。结论:C-erbB-2、nm23的表达与乳腺癌生物学行为有关,可作为判断预后的良好参考指标。
Objective:To investigate the prognostic significance of C erbB 2 and nm23 expression in invasive breast cancer Methods:Expression of C erbB 2 and nm23 in 72 cases of invasive breast cancer were examined by immunohistochemistry method Results:The positive rates of C erbB 2 and nm23 protein in breast cancer were 58 3% and 33 3%,respectively The expression of C erbB 2 was positively related to tumor size and axillary lymph node metastasis,while negatively related to survival nm23 expression was negatively related to axillary lymph node metastasis and C erbB 2 expression,while positively related to survival,but had no relation to tumor size C erbB 2 and nm23 expression were not related to pathological type of breast cancer Conclusions:C erbB 2 expression was associated with malignant biological behavior and poor prognosis in breast cancer On the contrary,nm23 expression was associated to better prognosis
出处
《广西医科大学学报》
CAS
1999年第6期780-781,共2页
Journal of Guangxi Medical University
