摘要
目的:研究有或无转移性皮肤癌nm23-H1的表达可否作为预后判断的指标。方法:用免疫组织化学技术SP法检查38例基底细胞癌及71例皮肤鳞状细胞癌,比较其nm23-H1过表达率。结果:基底细胞癌过表达率71%(30/38),无转移鳞癌过表达率68%(26/44),有转移鳞癌为0.8%(1/12)。但阴茎鳞癌nm23-H1过表达并不降低转移率。结论:抑制转移基因nm23-H1)过表达与皮肤癌转移呈反相关,差别有显著意义,可作为判断预后指标之一。
Objective:To study the expression of nm23 H 1 in carcinoma of the skin with or without metastasis and find out whether it is a prognostic factor Methods:[WT5,5”BZ]The expression of nm23 H 1 protein was examined by means of SP immunohisto chemical techique in 38 basal cell carcinomas (BCC) and 71 squamous cell carcinomas (SCC) with or without metastasis,and compare their overexpression rates Results:[WT5,5”BZ]nm23 H 1 protein overexpression rate in BCC was 71%(30/38),in SCC without metastasis was 68%(26/44),with metastasis was 0 8%(1/12) However in the penile SCC without and with metastasis the overexpression rates were 80%(4/5) and 50%(5/10) respectively Conclusion:[WT5,5”BZ]Antimetastatic gene nm23 H 1 overexpression is inversly associated with the metastasis of skin cancer,the differences are significant P<0 05 It is a good factor to distinguish prognosis,but not including penile cancer
出处
《广西医科大学学报》
CAS
1999年第6期771-772,共2页
Journal of Guangxi Medical University
