摘要
目的评价不稳定性心绞痛应用瑞舒伐他汀治疗的疗效及对血脂和同型半胱氨酸(Hcy)的影响。方法将124例不稳定性心绞痛患者随机分成对照组和观察组各62例,对照组应用常规综合治疗,观察组在对照组治疗基础上同时使用瑞舒伐他汀10 mg口服,1次/d,对两组患者8周后的血脂和同型半胱氨酸以及临床疗效进行比较。结果观察组和对照组治疗后TG、TC及LDL-C、同型半胱氨酸较治疗前降低,HDL-C较治疗前升高,治疗后观察组较对照组改变明显,差异有统计学意义(P<0.05);观察组临床疗效优于对照组,差异有统计学意义(P<0.05)。结论瑞舒伐他汀增强治疗不稳定性心绞痛的效果,减少发生不稳定性心绞痛的危险因素。
Objective To evaluate the clinical efficacy of rosuvastatin in patients with unstable angina and effect on the levels of lipid and homoeystein. Methods 124 patients with unstable angina were divided randomly into observation group and control group.Control group was given comprehensive traditional supportive treatments.Based on control group, observation group was treated with rosuvastatin orally 10 mg once a day.1 time per night.The levels of lipid, homocystein and the efective rate of treat were compared 8 weeks after treatment. Results After the treatment, the levels of TG, TC and LDL-C in two groups were lower than those before the treatment, HDL-C was higher than that before the treatment. After the treatment, the changes in observation group is higher than that in control group, the efective rate of treat in observation group is higher than that in control group.the difference between the two groups was significantly （P〈0.05）. Conclusion Rosuvastatin can enhance the clinical efficacy of patients with unstable angina and reduce the risk factors of the unstable angina.
出处
《中国现代药物应用》
2014年第3期18-20,共3页
Chinese Journal of Modern Drug Application
