期刊文献+

基因导向的乳腺癌治疗进展研究 被引量:4

暂未订购
导出
摘要 乳腺癌是我国妇女恶性肿瘤发病率排第一的癌症,根据WHO的数据显示,2008年,中国妇女乳腺癌的发病率为21.6/10万人,新增病例达16.9万例,死亡人数为4.5万例;根据现有研究报道,有5%~10%的乳腺癌和10%~15%的卵巢癌是由BRCA1/2突变引起的,而在乳腺癌和卵巢癌高发家族中,80%的患者BRCA1/2基因存在突变。该突变基因的携带者到50岁时乳腺癌发病率为33%~50%、到了70岁增长为56%~87%。中国妇女卵巢癌的发病率为3.8/10万人,新增病例2.8万例,死亡人数为1.1万。而沿海发达地区的发病率明显高于内陆地区。中国是乳腺癌发病率增长最快的国家之一,中国抗癌协会公布的统计数字显示,我国近年来乳癌发病率正以每年3%的速度递增,成为城市中病死率增长最快的癌症,发病年龄也呈逐渐年轻化的趋势。乳腺癌的治疗方法有很多:手术治疗、放射治疗、分子靶向治疗以及内分泌治疗。本文主要根据现代治疗方法的新理念来进行研究。
出处 《中国医药指南》 2014年第6期39-39,共1页 Guide of China Medicine
  • 相关文献

参考文献3

二级参考文献11

  • 1吕大鹏,徐光炜.乳腺癌普查的国内外进展[J].中国实用外科杂志,2006,26(1):68-70. 被引量:65
  • 2郭小毛,梅欣,章倩.局部晚期乳腺癌的治疗进展[J].中国癌症杂志,2006,16(6):409-416. 被引量:35
  • 3Fisher B,Brown A,Mamounas E,et al.Effect of preoperative chemotherapy on local-regional diseases in women with operable breast cancer finding from nation surgical adjuvant and bowel project B-18[J].J Clin Oncol,1997,15(7):2483-2493.
  • 4Hutcheon AW,Heys SD,Sarkar TK.Neoadjuvant docetaxel in locally advanced breast cancer[J].Breast Cancer Res Treat,2003,79(1):19-24.
  • 5Elledge RM,Mc Guuie WL.Prognostic factors and therapeutic decisions in axillary node-negative breast cancer[J].Annu RevMed,1993,44:2011.
  • 6Early Breast Cancer Trialistsp Collaborative Group.Polychemotherapy for early breast cancer:An over view of the randomized trials[J].Lancet,1998,352:930.
  • 7Smith RE,Bryant J,DeCillis A,et al.Acute myeloid leukemia and myelodysplastic syndrome after doxorubicin-cyclophosphamide adjuvant therapy for operable breast cancer:the National Surgical Adjuvant Breast and Bowel Project Experience[J].J Clin Oncol,2003,21(7):1195-1204.
  • 8Henderson IC,Berry DA,Demetri GD,et al.Improved outcomes from adding sequential paclitaxel butnot from escalating doxorubicin dose in an adjuvant chemotherapy regmen for patients with node-positive primary breast cancer[J].J Clin Oncol,2003,21(6):976-983.
  • 9Jean MN,Tadeuz P,John M,et al.Phase Ⅲ trial comparing TAC(docetaxel,doxorubicin,cyclophsphamide)with FAC(5-fluorouracil doxorubicin,cyclophsphamide)positive breast cancer (BC) patients:interim analysis of the BCIRG001 study[J].Proc Am Soc Clin Oncol,2002,21:36a.
  • 10Jassem J,Pienknowski T,Pluzanska A,et al.Doxorubicin and paclitaxel versus fluorouracil,doxorubicin,and cyclophosphamide as first-line therapy for women with metastatic breast cancer:final results of a randomized phase Ⅲ multicenter thail[J].J Clin Oncol,2001,19(6):1707-1715.

共引文献3

同被引文献34

  • 1李红智,郑易,林鹏,豆长明,董杰影,王彤文.赫赛汀诱导乳腺癌细胞凋亡及对其细胞周期的影响[J].基础医学与临床,2007,27(11):1251-1256. 被引量:8
  • 2Diéras V,Harbeck N,Budd GT,et al.Trastuzumab Emtansine in Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer:An Integrated Safety Analysis[J].J Clin Oncol,2014,32(25):2750-2757.
  • 3Samuel TA,Stone E.Is the era of HER2over?Pertuzumab in the neoadjuvant treatment of early HER2-positive breast cancer[J].J Community Support Oncol,2014,12(3):78-81.
  • 4Wheler JJ,Moulder SL,Naing A,et al.Anastrozole and everolimus in advanced gynecologic and breast malignancies:activity and molecular alterations in the PI3K/AKT/mTOR pathway[J].Oncotarget,5(10):3029-3038.
  • 5Kotler BM,Kerstetter JE,Insogna KL.Claudins,dietary milk proteins,and intestinal barrier regulation[J].Nutr Rev,2013,71(1):60-65.
  • 6Jo VY,Cibas ES,Pinkus GS.Claudin-4immunohistochemistry is highly effective in distinguishing adenocarcinoma from malignant mesothelioma in effusion cytology[J].Cancer Cytopathol,2014,122(4):299-306.
  • 7Lee KW,Lee NK,Kim JH,et al.Twist1causes the transcriptional repression of claudin-4with prognostic significance in esophageal cancer[J].Biochem Biophys Res Commun,2012,423(3):454-460.
  • 8Ersoz S,Mungan S,Cobanoglu U,et al.Prognostic importance of Claudin-1and Claudin-4expression in colon carcinomas[J].Pathol Res Pract,2011,207(5):285-289.
  • 9Li C,Yang W,Zhang J,et al.SREBP-1has a prognostic role and contributes to invasion and metastasis in human hepatocellular carcinoma[J].Int J Mol Sci,2014,15(5):7124-7138.
  • 10Trotter K,Schneider SM,Turner BS.Group appointments in a breast cancer survivorship clinic[J].J Adv Pract Oncol,2013,4(6):423-431.

引证文献4

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部