摘要
目的 :考察新型酒石酸美托洛尔缓释片 (MT)在不同实验条件下的体外释放情况。方法 :采用正交试验设计和紫外分光光度法考察MT在不同介质、不同转速及不同方法中的释放度。结果 :对MT体外释放影响大小依次为介质、方法、转速。结论 :释放机制均属于偏正转运。
OBJECTIVE:To investigate the drug-release of a new metoprolol tartrate extended release tablet (MT) on different conditions. METHODS:Using orthogonal experiment design, we determined the drug-release of MT with different media, rotate speeds and methods. RESULTS:The biggest affection of drug-release was medium, then method and rotate speed. CONCLUSIONS:The mechanism of drug-release belonged to the anomalous transport.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2001年第2期77-79,共3页
Chinese Journal of Hospital Pharmacy
