摘要
目的 :观察膨体聚四氟乙烯 (expanded polytetrafluoroethylene,e PTFE)对预防椎板切除术后硬膜粘连的效果 ,并和自体游离脂肪、空白对照比较。方法 :8只成年新西兰白兔 ,在 L2、3、L3、4和L4、5 椎板间开窗 1.0 cm× 0 .5cm大小 ,分别覆盖膨体聚四氟乙烯 ,自体游离脂肪和空白对照 ,术后 2、4、6、8周处死动物取材 ,并进行大体观察、组织学观察和透射电镜观察。结果 :在对照组观察到硬膜外有广泛的纤维粘连。脂肪组早期可见到存活的脂肪组织 ,使瘢疤与硬膜分开 ,晚期存活的脂肪组织部份萎缩 ,纤维化和硬膜粘连。 e PTFE组 ,硬膜表面光滑 ,硬膜外间隙存在 ,6、8周时可见骨再生。结论 :膨体聚四氟乙稀是一种生物相容性极佳 ,可以始终保持结构稳定 ,可防止成纤维细胞穿透 ,为二次手术提供了可分离的安全界面。是较理想的防粘连材料。游离脂肪可减少硬膜外瘢痕组织粘连 。
Objective:[WT5BZ][ST5BZ]To observe the effectiveness of (expanded polytetrafluoroethylere (ePTFE) in preventing epidural fibrosis after laminectiomy and compared the results to those obtained using free fat graft and nonimplanted control subjects.[WT5HZ]Method:[WT5BZ]1.0cm×0.5cm Laminectomies were perfomed in eight adult New Zealand rabbits at L 2、3 、L 3、4 and L 4、5 .The epidural cavity following laminectomy covered by ePTFE、 free fat and no coverings in the control group.The animals were sacrfifeced at 2、4、6、8 weeks postoperatively.The speciments were prepared for gross dissection,histological study and electron scanning microscopy.[WT5HZ]Result:[WT5BZ]The nonimplanted control sites demonstrated extensive fibrous tissue filling of the laminectomy defect.Free fat graft was an effective barrier to scar formation at early time periods,however,progressive fat graft degradation with some increased scarring was observed at latter time periods.The results showed that the drua was smooth and a “gap” was formed in the epidural cavity in ePTFE groups.New bone formation was observed at sixth and eighth weeks.[WT5HZ]Conclusions:[WT5BZ]Expanded polytetrafluoroethylene membrane is biolompatible,maintains its structural integrity,and is impervious to fibrous in growth.The membrance also provides a plane of dissection in cases requiring reoperation.It is indeal meterial in prevention of epidural fibrosis. [WT5HZ]
出处
《河北医学》
CAS
2001年第1期1-4,共4页
Hebei Medicine
关键词
膨体聚四氟乙烯
脂肪移植
硬膜外粘连
椎板切除膜
Expanded polytetrafluoroethylene
Fat graft
Peridural fibrosis
Post laminectimy membrane
