摘要
目的：研究利用医院信息系统监测分析药物性肝损伤的特点。方法：从医院信息系统数据库中提取2011年9月20-30日间丙氨酸氨基转移酶、门冬氨酸氨基转移酶、总胆红素、结合胆红素、碱性磷酸酶和γ-谷氨酰转移酶异常的住院患者资料，进行回顾性分析。结果：可能发生药物性肝损伤的有147例，主要分型为肝细胞性肝损伤。涉及11个科室、13类药物，居首位的是抗菌药。结论：本方法可有效挖掘药物性肝损伤发生的信息，使用计算机自动监测预警药品不良反应有着广泛的应用前景。
Objective：To study a way to monitor and analyze the characteristics of drug induced liver injury by using the hospital information system. Methods：The data of inpatients with abnormal ALT, AST, TB, CB, ALP, GGT were extracted from HIS database from Sept. 20, 2011 to Sept. 30, 2011 and analyzed retrospectively. Results： 147 drug induced liver injury incidents were concerned with 13 kinds of drugs and 11 departments. The major type of drug induced liver injury was hepatocellular injury and the major kind of drugs was antibiotics. Conclusion： The information of drug induced liver injury could be effectively obtained in this way. The technology of using computer automatically to monitor adverse drug reactions had its broad application prospect.
出处
《药物流行病学杂志》
CAS
2014年第2期88-91,共4页
Chinese Journal of Pharmacoepidemiology
关键词
医院信息系统
药品性肝损伤
药物不良反应
分析
Hospital information system
Drug induced liver injury
Adverse drug reaction
Analysis
