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高脂血症患者血清黏附分子、超敏C反应蛋白、同型半胱氨酸的检测及其临床意义 被引量：9

Detection and clinical significance of cell adhesion,high sensitivity C-reactive protein,homocysteinein in high lipoproteins
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摘要 目的:探讨高脂血症患者细胞间黏附分子-1(ICAM-1)、血管细胞黏附分子-1(VCAM-1)、E-选择素、超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)与低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)的相互关系及临床意义。方法:收集112例患者的临床资料,其中高胆固醇血症患者53例和高甘油三酯血症者59例,检测其血清中胆固醇(TC)、LDL-C、TG、HDL-C、ICAM-1、VCAM-1、E-选择素、hs-CRP、Hcy的水平,同时选择62例健康体检者作为健康对照组,应用统计学方法对两组检测结果进行比较分析。结果:高胆固醇血症组血清ICAM-1、VCAM-1、E-选择素、hs-CRP、Hcy明显高于高甘油三酯血症组和健康对照组,差异有统计学意义(P<0.001);与健康对照组相比,高甘油三酯血症患者ICAM-1、VCAM-1、E-选择素、hs-CRP及Hcy升高并不明显,差异无统计学意义(P>0.05),但是hs-CRP明显高于健康对照组,差异有统计学意义(P<0.05)。相关分析表明:LDL-C与ICAM-1、VCAM-1、E-选择素、hs-CRP及Hcy呈正相关性(r值分别为0.854、0.631、0.810、0.691、0.401,均P<0.001);HDL-C与ICAM-1、VCAM-1、E-选择素、Hcy呈负相关性(r值分别为-0.230、-0.262、-0.232、-0.281,均P<0.05);TG与ICAM-1、VCAM-1、E-选择素、hs-CRP、Hcy无相关性。结论:与高甘油三酯血症患者和健康对照组相比,高胆固醇血症患者血ICAM-1、VCAM-1、E-选择素、hs-CRP、Hcy升高,这些患者更容易罹患心血管疾病。 Objective：To analyze the relationship among cell adhesion facator、high sensitivity C-reactive protein、homocysteinein and low density lipoprotein cholesterol、high density lipoprotein cholesterol、triglycerides.Methods： We determined TC、LDL-C、TG、HDL-C、ICAM-1、VCAM-1、Hcy、hs-CRP、E-selection levels of 112 patients and 62 control group.Results ：ICAM-1、VCAM-1、Hcy、hs-CRP、E-selection levels with hypercholesterlemia were statistically significantly higher than the hypertriglyceridemia （P〈0.001）and control group（P〈0.001）;Comparison of subjects with hypertriglyceridemia with the subjects in the control group did not yield a significance difference in terms of ICAM-1、VCAM-1、Hcy、E-selection,but hs-CRP value was higher（P〈0.001）.Pearson＇s correlation analysis revealed that LDL-C levels were correlated with ICAM-1、VCAM-1、Hcy、hs-CRP、E-selection in the whole study group;TG levels were not correlated with ICAM-1、VCAM-1、Hcy、E-selection;HDL-C levels were a negative correlation with ICAM-1、VCAM-1、Hcy、hs-CRP、E-selection.Conclusion：The increase of Hcy、E-selection、VCAM-1、ICAM-1、 hs-CRP in hypercholesterlemia reflects their high cardiovascular risk,compared with hypertriglyceridemiaand the control group.
作者 徐鑫 贺恒鹏 刘勇
机构地区 中国医科大学附属盛京医院检验科 中国医科大学附属第四医院检验科
出处 《现代医学》 2014年第1期38-41,共4页 Modern Medical Journal
关键词 高脂血症 粘附分子 同型半胱氨酸 超敏C反应蛋白 high lipoproteins adhesion molecule high sensitivity C-reactive protein homocysteinein
分类号 R589.2 [医药卫生—内分泌]
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参考文献14

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现代医学
2014年 第1期

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