摘要
目的:观察结缔组织生长因子肽(P1c)对大鼠凝血参数的影响。方法:将SD大鼠随机分为5组:P1c低、中、高剂量组,肝素钠组和生理盐水组,实验大鼠连续5 d分别静脉注射低、中、高剂量(2、4、8 mg·kg-1)的P1c,肝素钠(50 U·kg-1)和等体积的生理盐水,测定各组凝血参数并进行比较。结果:肝素钠组与生理盐水组凝血参数比较,差异有统计学意义(P<0.05),低、中、高剂量的P1c组凝血参数与生理盐水组比较差异均无统计学意义(P>0.05)。结论:P1c对大鼠凝血参数无明显影响。
Objective： To observe the effects of connective tissue growth factor peptide（P1c） on the blood conglomeration parameters in rats. Methods： P1c was injected via the femoral vein of rats at the dose of 2,4,and 8 mg？kg-1 for five days.The serum level of prothrombin time （PT）, activated partial thromboplastin time （APTT）,fibrinogen （FIB） and thrombin time （TT） were measured. Results： The positive heparin groups showed significant difference as compared with the normal saline groups（p〈0.05）.While no significant difference was noted between the groups of low middle and high dose of P1c and the normal saline groups（p〉0.05）. Conclusion： P1c has no side effect on coagulation system.
出处
《现代医学》
2014年第1期1-3,共3页
Modern Medical Journal
基金
国家自然科学基金资助项目(30970809)
关键词
结缔组织生长因子肽
凝血参数
大鼠
connective tissue growth factor peptide
coagulation parameters
rats
