摘要
目的 探讨血清降钙素原（PCT）在支气管哮喘急性发作诊断和治疗中的临床意义.方法 将82例支气管哮喘急性发作患者分为两组,每组41例,PCT组根据患者血清PCT水平决定抗生素应用,对照组按照抗生素应用指南决定抗生素治疗方案,比较两组患者临床有效率、抗生素使用率、住院时间和住院费用,比较PCT组不同病情患者抗生素使用率.对两组患者出院后随访1个月,比较复发率.结果 两组患者治疗有效率及住院时间比较差异无显著性（P＞0.05）,PCT组抗生素使用率及住院费用均低于对照组,差异均有显著性（P＜0.05）;抗生素使用率组内比较,PCT组轻度～中度患者低于重度～重危患者,差异有显著性（P＜0.05）,两组复发率比较差异无显著性（P＞0.05）.结论 血清PCT检测可准确判断支气管哮喘急性发作患者是否存在细菌感染,并指导抗生素应用,在支气管哮喘急性发作的治疗中具有重要意义.
Objective To explore the clinical significance of serum procalcitonin（PCT） in the diagnosis and treatment of acute attack of bronchial asthma. Methods A total of 82 patients with acute attack of bronchial asthma were divided in- to two groups, 41 cases in each group, the PCT group were treated with antibiotics according to serum PCT levels of the patients, the control group were decided to use antibiotics therapy according to the guidelines of antibiotics, the clinical efficiency, the rate of antibiotics usage, hospital stay and hospital costs, and the rate of antibiotics usage of patients with different diseases in the PCT group were compared. Followed-up all the patients for 1 month, compared the recur- rence rate. Results Compared the treatment efficacy and hospital stay of the patients in the two groups, the difference was not significant （P〉0.05）, the rate of antibiotics usage and hospital costs of the PCT group were lower than that of the control group（P〈0.05）, the difference was significant; The rate of antibiotics usage was compared between the group, the mild and the moderate patients were lower than the severe and the critically ill patients of the PCT group （P〈0.05）, the difference was significant, compared the recurrence rate between the two groups, there was no significant difference （P〉0.05）. Conclusion Serum PCT detection can accurately judge whether there is bacterial infection in patients with a- cute attack of bronchial asthma or not, and it can guide the use of antibiotics, it has a great significance in the treat- ment of acute attack of bronchial asthma.
出处
《中国现代医生》
2014年第8期19-21,共3页
China Modern Doctor
基金
浙江省卫生厅医药卫生计划项目(2013KYA170)
关键词
降钙素原
支气管哮喘急性发作
抗生素
Procalcitonin
Acute attack of bronchial asthma
Antibiotics
