摘要
目的定量检测血浆中D二聚体(D-dimer,D-D)的水平,研究其在急性/非急性心血管系统疾病中的差异,从而了解其在心血管系统疾病中的诊断价值。方法对2012年6月至2012年11月在我院就诊252例心血管患者的血浆D-D水平进行了检测,分析比较不同疾病血浆D-D的差异性,同时为辨别急性/非急性心血管疾病寻找最佳的临界值。结果急性心血管疾病组D-D升高明显高于非急性心血管疾病组(χ2=31.942,P<0.001),且ROC曲线分析结果提示D-D在755μg/L具有较好的判别意义(AUC=0.709,P<0.001)。结论测定患者血浆中的D-D水平,可以作为心血管疾病患者,尤其是急性心血管病患者纤溶亢进的指标,同时有助于判断病情严重程度和预后。
Objective Quantitative determination of plasma D- dimer （ D-dimer, D- D） level to study the differences in the acute / non-acute cardiovascular diseases,to understand the value of the diagnosis of cardio- vascular diseases. Method June 2012 to November 2012 in our hospital for treatment of 258 cases of patients with cardiovascular plasma D-D levels were detected, and comparing different diseases of the differences be- tween plasma D-D,at the same time looking for the best threshold to distinguish between acute / non-acute cardiovascular diseases. Results Acute cardiovascular diseases elevated D-D were significantly higher than the non-acute cardiovascular diseases group （X2 = 31. 942, P 〈 0. 001 ） , and the ROC curve analysis showed that D-D cutoff point 755μg / L has good judgment significance（AUC =0. 709,P 〈0. 001 ）. Conclusion Determination of D-D levels in the plasma of patients, can be used as cardiovascular diseases, especially acute cardiovascular diseases the hyperfibrinolysis indicators, while helping to speculate that the disease severity and prognosis.
出处
《血栓与止血学》
2014年第1期29-32,共4页
Chinese Journal of Thrombosis and Hemostasis
关键词
D二聚体
心血管疾病
急性
非急性
D- dimer
Cardiovascular diseases
Acute
Non- acute
