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质谱技术在感染性疾病诊断中的应用进展 被引量：4

Application progress of mass spectrometry in the diagnosis of infectious disease
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摘要 质谱(mass spectrometry,MS)技术,尤其是基质辅助激光解吸电离飞行时间质谱(matrix assisted laser desorption/ionization time of flight mass spectrometry,MALDI-TOF MS),具有简便、快速及特异地分析微生物生物大分子标记物质谱图,从而实现临床微生物检验中细菌、真菌及病毒在属、种、株水平上的鉴定。MS在菌血症、尿路感染、毒素检测及耐药监测方面显示出巨大的优势,有望成为临床微生物实验室感染性疾病常用诊断方法。 Mass-spectrometric techniques, especially the matrix assisted laser desorption/ionization time of flight mass spec-trometry （MALDI-TOF MS） analyze the mass spectrum of the biomarkers of microorganism conveniently, rapidly and distinctly , demonstrating the identification of bacteria and fungus at level of genus,species and strain. In bacteremia, urinary tract infections, toxin detection and drug resistance monitoring,MS shows great advantage, making it commonly-used diagnostic method of infec-tious diseases for clinical microbiology laboratory hopefully.
作者 杭亚平 胡龙华 王小中
机构地区 南昌大学第二附属医院检验科
出处 《实验与检验医学》 CAS 2014年第1期1-4,共4页 Experimental and Laboratory Medicine
基金 江西省自然科学基金项目(编号:20132BAB205062)
关键词 微生物鉴定 感染性疾病 应用进展 MALDI-TOF MS Matrix assisted laser desorption/ionization time of flight mass spectrometry Microbial identification Infectious disease Application progress
分类号 R446 [医药卫生—诊断学]
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参考文献25

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二级参考文献28

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共引文献29

同被引文献54

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引证文献4

二级引证文献7

实验与检验医学
2014年 第1期

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