摘要
细丝蛋白A(filamin A,FLNa)是在非肌性细胞中发现的第一个肌动蛋白交联蛋白。其可与90多种配体结合,包括通路蛋白、细胞内信号分子及转录因子等,具有整合细胞力学和信号转导的作用。FLNa所结合的配体分布广泛,当其发生突变时可导致包括恶性肿瘤等严重后果。
Filamin a （FLNa） is the first non-muscle actin filament cross-linking protein. It has over 90 binding partners including channels, receptors, intracellular signaling molecules and even transcription factors, which play a role in conformity cell mechanics and signal transduction. Due to this diversity, mutations in human FLNa genes can result in a wide range of anomalies with moderate to lethal consequences including malignant tumor. This review focuses on the research progress of molecule structure and functions of FLNa in diseases development.
出处
《临床与病理杂志》
CAS
2014年第1期87-92,共6页
Journal of Clinical and Pathological Research
基金
国家自然科学基金(81071846)
河北省自然科学基金(H2013505059)
河北省科技厅国际合作项目(12396107D)
吴阶平医学基金(320.6750.12604)~~
关键词
细丝蛋白A
结构
功能
恶性肿瘤
filamin A
structure
function
malignant tumor
