摘要
目的:探讨小剂量甲状腺素在老年慢性心力衰竭(CHF)伴低甲状腺激素水平患者中对心功能的影响。方法:将92例CHF伴低甲状腺激素水平患者随机分为观察组(n=46)与对照组(n=46),对照组给予常规抗心力衰竭治疗,观察组在对照组基础上加用小剂量左甲状腺素钠治疗,对比两组患者心功能变化。结果:观察组总有效率为89.1%(41/46),显著高于对照组的67.4%(31/46)(P<0.05);两组患者治疗后每搏输出量(SV)、每分输出量(CO)、心脏指数(CI)、左室射血分数(LVEF)、舒张早期速度峰值(VE)/舒张晚期速度峰值(VA)等心功能指标均有显著改善(P<0.01),但治疗后观察组仍显著优于对照组(P<0.05)。结论:在常规抗心力衰竭治疗基础上加用低剂量甲状腺素将有效改善老年CHF伴低甲状腺激素血症患者心功能,降低死亡率,提高患者生活质量。
Objective To discuss the clinical effects of low-dose thyroxine on cardiac function in patients with CHF and low thyroid hormone levels.Methods 92 patients with CHF and low thyroid hormone levels were randomly divided into the observation group（n=46） and the control group（n=46）,the control group were treated with conventional anti-heart failure therapy, and the observation group were treated with low-dose thyroxine based on the control group,and then the clinical effects was contrasted between the two groups.Results Total efficiency of the observation group was 89. 1%（41/46）,significantly higher than 67.4%（31/46）（P 〈 0.05）;after the treatment, SV, CO,CI,LVEF, and VE/VA were significantly better than before in the two groups（P 〈 0.01）,and the observation group were significantly better than the control group after the treatment（P 〈 0.01）.Conclusion Low-dose thyroxine based on the conventional anti-heart failure therapy can effectively improve the cardiac function,reduce mortality, and improve the quality of life in patients with CHF and low thyroid hormone levels.
出处
《吉林医学》
CAS
2014年第6期1128-1130,共3页
Jilin Medical Journal
