摘要
目的 探讨胃癌患者血清SiSo细胞表达的受体结合肿瘤抗原（RCAS1）表达水平及临床意义.方法 采用酶联免疫吸附试验法（ELISA）检测61例胃癌患者血清RCAS1水平,以31例正常人作为对照,并比较38例胃癌患者手术前后血清RCAS1水平.结果 胃癌患者血清RCAS1水平[（40.46±13.83） U/ml]明显高于正常对照组[（14.09 ±4.66） U/ml],两者差异有统计学意义（P＜0.01）;血清RCAS1水平与胃癌患者性别、年龄无明显相关,与胃癌患者临床分期、肿瘤细胞分化程度明显相关;Ⅳ期[（59.17±6.06） U/ml]明显高于Ⅲ期[（45.61±5.74） U/ml]、Ⅲ期明显高于Ⅱ期[（34.28±6.26）U/m]、Ⅱ期明显高于Ⅰ期[（22.02±8.38） U/ml]、Ⅰ期明显高于正常对照组[（14.09±4.66） U/ml],两两比较差异有统计学意义（P＜0.05）.肿瘤细胞分化程度较差（低分化腺癌、黏液腺癌）胃癌患者血清RCAS1水平[（45.19±13.38） U/ml]明显高于肿瘤细胞分化程度较好（高分化腺癌、中分化腺癌）胃癌患者[（36.70±13.19） U/ml];胃癌患者术后血清RCAS1水平[（31.74 ±9.59） U/ml]明显低于术前[（32.10±9.56） U/ml],两者差异有统计学意义（P＜0.01）.结论 RCAS1参与胃癌的发生发展过程.
Objective To investigate serum receptor-binding cancer antigen expressed on SiSo cells （RCAS1） in patients with gastric carcinoma and its clinical significance.Methods The level of serum RCAS1 was measured by Enzyme linked immunosorbent assay （ELISA） in 31 cases of normal control subject and 61 cases of patients with gastric carcinoma,compared with 38 cases of patients with gastric carcinoma pre-and post-operation.Results The levels of serum RCAS1 were elevated in all subgroups of patients with gastric carcinoma （40.46 ± 13.83） U/ml compared to the controls （14.09 ± 4.66） U/ml （P ＜0.01）,serum RCAS1 was correlated with TNM stage and histological grade,and not with sex and age; the serum RCASI level in stage Ⅳ （59.17 ±6.06） U/ml was higher in comparison with stage Ⅲ （45.61 ± 5.74） U/ml （P＜0.01）,in stage Ⅲ it was higher than that in stage Ⅱ （34.28 ±6.26） U/ml （P＜0.01）,in stage Ⅱ it was higher than that in stage Ⅰ （22.02 ±8.38） U/ml （P ＜0.01）,and in stage Ⅰ it was higher than that in normal control subject （14.09 ± 4.66） U/ml （P ＜ 0.05）,the level of serum RCAS1 was higher in the cases of poorly differentiated adenocarcinoma and mucoid adenocarcinoma （45.19 ± 13.38） U/ml than those in the cases of well differentiated and moderately differentiated adenocarcinoma （36.70 ± 13.19） U/ml （P ＜ 0.05）,the serum RCAS1 levels were remarkably reduced in patients with gastric carcinoma after operation （P ＜ 0.01）.Conclusion RCAS1 may take part in the malignant process of gastric carcinoma,it may be a predictor for biological behaviors and prognosis of gastric carcinoma.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2014年第3期524-525,共2页
Chinese Journal of Experimental Surgery
