摘要
目的观察乌灵胶囊治疗脑卒中后抑郁(PSD)的疗效。方法将106例PSD患者随机分为乌灵胶囊组和对照组。乌灵胶囊组在常规脑卒中治疗的基础上,加用乌灵胶囊990 mg,3次/d,对照组口服等量安慰剂,连续治疗6周。于治疗前及治疗后第2、4、6周和第3、6个月进行汉密尔顿抑郁量表(HAMD)及美国国立卫生研究院卒中量表(NIHSS)。结果乌灵胶囊组及对照组从第4周起HAMD评分及NIHSS评分显著低于治疗前(均P<0.05)。乌灵胶囊组第6周起HAMD评分显著低于对照组,第4周起NIHSS评分显著低于对照组(均P<0.05)。乌灵胶囊组各时间点总有效率均显著高于对照组(均P<0.05)。出现大便次数增多3例,口干、失眠、食欲减退、头晕、心慌各2例、恶心呕吐及头痛各1例。结论乌灵胶囊治疗PSD有效,不良反应少。
Objective To observe the curative effect of Wuling capsule （WL） to post-stroke depression （PSD）.Methods One hundred and six PSD patients were randomly divided into WL group and control group.On the basis of stroke conventional treatment,WL group was taken WL 990 mg 3 times a day,while control group was treated with the same dose of placebo,last for 6 weeks.Hamilton depression scale （HAMD） and national institutes of health stroke scale （NIHSS） were evaluated before and 2,4,6 weeks and 3,6 months after treatment.Results HAMD and NIHSS scores of WL group were significantly lower than those before treatment since 4th week （all P 〈 0.05）.HAMD scores of WL group were significantly lower than control group since 6th week,and NIHSS scores of WL group were significantly lower than control group since 4th week （all P 〈 0.05）.The total effective rates of WL group were significantly higher than control group at each time point （all P 〈 0.05）.The bowel movement number of times increases was in 3 cases; dry mouth,insomnia,anorexia,dizzy,flustered were in 2 cases respectively; nausea,vomiting and headache were in 1 case respectively.Conclusion WL is effective in treating PSD,and has less adverse reaction.
出处
《临床神经病学杂志》
CAS
北大核心
2014年第1期61-63,共3页
Journal of Clinical Neurology
关键词
乌灵胶囊
脑卒中后抑郁
疗效
Wuling capsule
post-stroke depression
curative effect
