摘要
目的 评价霉酚酸酯 (MMF)联合环孢菌素A(CsA)和短程甲氨蝶呤 (MTX)预防非亲缘异基因骨髓移植中急性移植物抗宿主病 (aGVHD)的有效性和安全性。方法 12例患者非亲缘异基因骨髓移植当天始联合应用MMF(骁悉胶囊 ) 1.0g/d ,CsA 3mg·kg-1·d-1,MTX移植后第 1天 15mg/次 ,移植后第 3,6 ,11天 10mg/次预防aGVHD。结果 12例非亲缘异基因骨髓移植患者中 ,1例于移植后第 7天发生Ⅳ度超急性GVHD ,2例分别于移植后第 10天和第 17天发生Ⅱ度aGVHD ,经甲泼尼龙和MMF治愈 ,其余患者未发生aGVHD。治疗中与MMF相关不良反应为白细胞减少 ,调整剂量后血常规得以恢复 ,不影响移植患者的造血重建。结论 在非亲缘异基因骨髓移植中应用MMF联合CsA、MTX预防aGVHD是有效的。
Objective To evaluate the efficacy and safety of mycophenolate mofetil(MMF) in combination with cyclosporine A(CsA) and methotrexate(MTX) for prevention of acute graft versus host disease(GVHD) after unrelated donor allogeneic bone marrow transplantation (allo BMT). Method Twelve cases of unrelated donor allo BMT were evaluated in a single center trial. The acute GVHD was prevented with 1 g MMF daily in addition to CsA 3?mg·kg -1 ·d -1 and MTX 10～15?mg at post BMT day1,day3,day6 and day11. Results Acute GVHD was found in one case(Grade Ⅳ) at the seventh day and two cases (Grade Ⅱ)at the tenth day and seventeenth day after BMT. These patients were treated with a combination of MMF,methyprednisolone and CsA. The common adverse hematologic events of MMF was leukopenia. Conclusion The preliminary study showed that MMF could be used effectively and safely for prevention of acute GVHD in unrelated donor allo BMT.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
2001年第2期76-78,共3页
Chinese Journal of Hematology
基金
浙江省科技厅重大资助!项目 (110 30 5 8)
浙江省医药卫生重点科技项目! (2 0 0 0ZD0 0 1)
