摘要
目的 了解气管、支气管类癌的临床生物学特性 ,探讨合理的手术指征及术式。 方法对 2 0例气管、支气管类癌患者的外科治疗结果进行综合分析。 结果 气管、支气管类癌的临床特点和一般肺癌相比缺乏特征性表现 ,免疫组化结果提示其为神经内分泌细胞来源。 2 0例均予以手术切除 ,根治性切除率 95 0 % ,手术并发症发生率 10 0 %。术后病理报告典型类癌 13例 ,淋巴结转移率为 2 3 1% ;不典型类癌 7例 ,淋巴结转移率为 3/ 7。 13例典型类癌的 5 ,10 ,15年生存率分别为10 0 0 %、7/ 8及 3/ 4。 7例不典型类癌中 ,6例存活患者术后尚未满 5年 ,1例术后 2年余死于远处转移。 结论 手术切除是治疗类癌的主要手段。手术指征不应限于Ⅲa期及分期较早患者 ,对可能切净的Ⅲb期患者也应尽早手术。术式的选择应主要考虑患者的年龄及肺功能状况 ,对年轻、肺功能正常者 ,应以手术根治性为目的 ,否则应选择保守术式。
Objective To understand the biologic and clinical characteristics of carcinoid tumor of trachea and bronchus and to find out rational surgical indications and approaches. Methods The clinical materials of 20 surgically treated patients with carcinoid of trachea and bronchus were retrospectively analyzed. [WT5”HZ]Results All but one patient received radical tumor resection. Operative complication occurred in 2 patients. Of the 20 patients, 13 suffered from typical carcinoids (TC) and 7 from atypical carcinoids (AC). Immunochemical staining revealed that both the typical and atypical carcinoids were of neuroendocrine origin. The 5-, 10- and 15-year survival rate of TC patients was 100.0%, 7/8 and 3/4 respectively. Of the 7 patients with AC, 6 had not yet been 5 years after operation but were still alive, and one patient died of remote metastasis 2 years after operation.Conclusion Surgical resection of carcinoid is indicated not only for early cases, but also for patients in stage Ⅲa and Ⅲb. The age and pulmonary function of the patients are the chief factors determining the surgical approach.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2001年第1期70-72,共3页
Chinese Journal of Oncology
关键词
气管肿瘤
支气管肿瘤
类癌
预后
外科手术
Trachea neoplasm/surgery
Bronchus neoplasm/surgery
Carcinoma, carcinoid/surgery
Prognosis
