摘要
目的 观察 U5 0 ,488H(选择性 κ-阿片受体激动剂 )对大鼠腹主动脉的舒张作用 ,并探讨其机制 .方法 采用离体血管灌流实验 ,测定血管张力的改变 .结果 1U5 0 ,488H对大鼠腹主动脉具有明显的舒张作用 ;2 U5 0 ,488H对大鼠腹主动脉的舒张效应依赖于内皮细胞的存在 ;3优降糖可明显抑制 U5 0 ,488H对大鼠腹主动脉的舒张作用 ;4U5 0 ,488H的舒张血管效应与 M受体、β受体、前列腺素及 NO无关 .结论 U5 0 ,488H是一种有效的扩血管物质 ,其舒张血管的效应具有内皮依赖性 ,且与 K+
AIM To investigate the relaxant effect of U50,488H (a selectiveκ opioid receptor agonist) on abdominal aorta and its underlying mechanism in the rat. METHODS Isolated abdominal aorta was perfused and the tension of the vessel was measured. RESULTS ①U50,488H had the significant dose dependent relaxant effect on rat abdominal aorta; ②The relaxant effect of U50,488H on rat abdominal aorta was endothelium dependent; ③The relaxant effect of U50,488H on rat abdominal aorta was inhibited in presence of glybenclamide; ④The relaxant effect of U50,488H on blood vessel bore no relationship to M receptor, β receptor, prostaglandin and nitric oxide (NO). CONCLUSION U50,488H is a powerful endothelium dependent vasodilator, related to K + ATP channels.
出处
《第四军医大学学报》
北大核心
2001年第1期29-32,共4页
Journal of the Fourth Military Medical University
