摘要
目的探讨血小板平均体积在老年重症社区获得性肺炎(SCAP)中的应用价值,为老年SCAP的严重程度提供更多的依据。方法老年SCAP组患者31例,老年非SCAP组75例,健康对照组55例,收集临床及实验室指标进行比较分析。结果老年SCAP组血小板平均体积(MPV)较对照组明显升高(10.46±1.01)fl vs(9.77±0.91)fl(P<0.01),老年SCAP组也较老年非SCAP组升高(10.46±1.01)fl vs(9.88±0.82)fl(P<0.01),老年非SCAP组和正常对照组差异无统计学意义。MPV工作者特征曲线(ROC)诊断老年SCAP的最佳界值为10.25fl,MPV大于10.25fl时敏感度54.8%,特异度73.3%,阳性诊断价值59.0%,阴性诊断价值12.0%,曲线下面积(AUC)0.666(P<0.01)。老年SCAP组MPV与白细胞计数呈正相关,与血小板计数、C反应蛋白无明显相关。结论 MPV作为一个简单指标一定程度反映了社区获得性肺炎的严重程度和炎症的程度,其在诊断老年SCAP中敏感性较低。
Objective Through discussing the value of mean platelet volume（MPV） applied to severe community-acquired pneumonia（SCAP） in elderly,it will provide more evidence for evaluation of the disease degree.Methods Clinical data and laboratory indexes were collected in 31 elderly patients with SCAP（SCAP group）,75 elderly non-SCAP patients（non-SCAP group） and 55 normal subjects（contro1 group）.Results MPV in SCAP group increased statistically significantly compared with that of non-SCAP and the control group,respectively （10.46±1.01） fl vs （9.77±0.91） fl（P〈0.01） and （10.46±1.01） fl vs （9.88±0.82） fl（P〈0.01）;however,the statistical significance did not find between non-SCAP and the control group.ROC curve analysis suggested that MPV cut-off point for making a diagnosis of SCAP was 10.25 fl,MPV〉10.25 fl with the sensitivity,specificity,positive predictive value（PPV）,and negative predictive value（NPV） respectively 54.8%,73.3%,59.0% and 12.0%.Positive correlation existed between the white blood cell count and MPV,but no obvious correlation was found with the platelet count,C reactive protein in SCAP elderly group.Conclusion MPV is a simple index and reflects the CAP severity and the inflammation degree,but the sensitivity is lower in the diagnosis of SCAP in elderly patients.
出处
《临床荟萃》
CAS
2014年第3期320-323,共4页
Clinical Focus
关键词
肺炎
社区获得性感染
血小板
老年人
pneumonia
community-acquired infections
blood platelets
aged
