摘要
目的:探讨隔药灸治疗原发性痛经的疗效及其生殖内分泌机制。方法:将171例原发性痛经患者随机分为隔药灸组、隔淀粉灸组和针刺三阴交组,每组57例。隔药灸组采用隔药灸神阙穴,隔淀粉灸组采用隔淀粉灸神阙穴,针刺三阴交组单纯针刺三阴交穴。观察治疗前后原发性痛经患者血清雌二醇(E2)、孕酮(P)以及前列腺素水平(PGF2α)的变化,并比较各组疗效。结果:隔药灸组疗效优于其他两组[痊愈率比较:89.8%(44/49)vs 60.0%(30/50),60.4%(32/53),均P<0.05];隔药灸组能降低患者E2含量[(110.99±12.90)pg/mL vs(83.94±8.91)pg/mL,P<0.05]、PGF2α含量[(24.58±3.01)pg/mL vs(14.34±1.48)pg/mL,P<0.01],升高P含量[(4.65±0.68)ng/mL vs(6.68±0.95)pg/mL,P<0.05];隔淀粉灸组和针刺三阴交组则主要降低患者PGF2α含量。对E2的调节,隔药灸组优于隔淀粉灸组及针刺三阴交组[(-30.16±10.20)pg/mL vs(10.79±15.01)pg/mL,(22.81±12.22)pg/mL,均P<0.05];对PGF2α的调节,隔药灸组优于隔淀粉灸组及针刺三阴交组[(-13.10±2.40)pg/mL vs(-6.52±1.88)pg/mL,(-3.14±1.19)pg/mL,均P<0.05];而对P水平的调节,隔药灸组及隔淀粉灸组优于针刺三阴交组(均P<0.05)。结论:隔药灸脐法治疗原发性痛经疗效显著,其机制与调节机体生殖内分泌水平有关,可降低血清E2、PGF2α含量,升高P含量。
Objective To explore the efficacy and the reproductive endocrinal mechanism of herbal-partitioned moxibustion in the treatment of primary dysmenorrhea. Methods One hundred and seventy-one cases of primary dysmenorrhea were randomized into an herbal-partitioned moxibustion group （group A）, an starch-partitioned moxibustion group （group B） and an acupuncture group （group C）, 57 cases m each one. In the group A, moxi- bust＋on isolated with herbal medicine was applied to Shenque （CV 8）. In the group B, moxibustion isolated with starch was used at Shenque （CV 8）. In the group C, acupuncture was given at Sanyinjiao （SP 6）. The changes of estradiol （E2）, progesterone （P） and prostaglandin levels （PGF2α） were observed before and after treatment, and the therapeutic effects were compared among the 3 groups. Results The therapeutic effect in the group A was bet- ter than those in the other two groups rcompared the cured rate： 89.8% （44/49） vs 60.0% （30/50）, 60.4% （32/53）, both P〈0.05]. In the group A, E2 level [-（ 110.99± 12.90） pg/mL vs （83.94 ± 8.91） pg/mL, P〈 0.05] and PGF2a level [（24. 58±3. 01） pg/mL vs （14.34±1.48） pg/mL, P〈0. 01] were decreased and P level was increased [-（4.65±0.68） ng/mL vs （6.68±0.95）pg/mL, P〈0.05]. In the group B and C. PGF2α
level were reduced. Concerning to the regulating of E2 and PGF2a levels, the results in the group A were better than those in the group B and C [-（-30. 16 ± 10.20） pg/mL vs （10. 79± 15.01） pg/mL, （22.81±12. 22） pg/mL; （-13.10±2.40） pg/mL vs （ 6.52±1.88） pg/mL, （-3.14± 1.19） pg/mL,均 P〈0.05]. Concerning to the regulation of P level, the results in the group A and B were better than that in the group C （all P〈0.05）. Conclusion The herbal-partitioned moxibustion achieves the significant efficacy on primary dysmenorrhea, which could be related to regulating the reproductive endocrinal level. It decreases E2 and PGF2α levels and increases P level.
出处
《中国针灸》
CAS
CSCD
北大核心
2014年第3期209-212,共4页
Chinese Acupuncture & Moxibustion
基金
国家重点基础研究发展计划(973)项目:2007CB 512703
关键词
原发性痛经
隔药灸
生殖内分泌
primary dysmenorrhea
herbal-partitioned moxibustion
reproductive endocrine
