摘要
目的 :探讨活动性结核患者血清可溶性 TNF受体 - (s TNFR- )水平的变化。方法 :用双抗体夹心EL ISA法检测血清 s TNFR- 水平。结果 :活动性结核 ,特别是播散性结核患者血清 s TNFR- 水平较正常对照组明显增高 (P <0 .0 1) ;随诊观察抗结核治疗后 ,患者血清 s TNFR- 水平有不同程度下降。结论 :监测血清 s TNFR-
Objective: Our purpose was to study the concentration of soluble tumor necrosis factor receptor Ⅰ(sTNFR Ⅰ) in the serum of patients with acute tuberculosis. Methods: The levels of soluble TNFR Ⅰ in serum were measured in 11 patients with acute tuberculosis. Concentration of sTNFR Ⅰ were measured by using enzyme linked immunological binding assay. Results: In patients with acute tuberculosis, especially severe tuberculosis, serum levels of sTNFR Ⅰ increased significantly (P<0.01), compared with those of control. After antituberculosis therapy, serum levels of sTNFR Ⅰin patients with acute tuberculosis decreased by various degrees. Conclusion: Measurements of sTNFR Ⅰ in serum of patients with acute tuberculosis could be an important index in the judgement of the outcome of the disease.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2001年第1期36-37,共2页
Journal of China Medical University
关键词
活动性结核病
血清
STNFR-I
ELISA
临床研究
soluble tumor necrosis factor receptor Ⅰ
acute tuberculosis
enzyme linked immunological binding assay
