摘要
目的:探讨多系统萎缩(multiple system atrophy,MSA)患者的临床表现和诊断方法。方法:回顾性分析近3年来郑州大学第一附属医院收治的68例MSA患者的临床资料并结合文献复习。结果:MSA患者自主神经功能障碍57例(83.8%),其中46例患者(67.6%)出现泌尿生殖功能障碍;以帕金森综合征为主的MSA-P亚型23例占总人数33.8%,以小脑性共济失调为主的MSA-C亚型45例占总人数66.2%;头部MRI可见T2信号典型改变:壳核背外侧条带样低信号、外侧缘裂隙样高信号、小脑萎缩、小脑中脚高信号、脑桥基底部"十字征"。结论:MSA是多系统受累的神经变性疾病,其症状复杂多样。临床诊断需详细病史及神经系统检查,并以磁共振成像等辅助手段加以支持。
Objective： To investigate the clinical manifestations, diagnosis of patients with multiple system atrophy （MSA）. Methods： Clinical data of 68 MSA cases were retrospectively analyzed combined with literature review. Results： There were 57 MSA patients （83.8%） accompanied by autonomic nervous dysfunction, including 46 patients with urogenital dysfunction. 23 MSA-P sub- type patients（33.8% ） mainly appeared as parkinson＇ s syndrome while 45 MSA-C subtype pa- tients（66.2% ） mainly appeared as cerebellar ataxia. Typical T2 signal of cerebral MRI showed band-shaped low signal in the dorsal lateral putamen, fissure-shaped high signal in the lateral bor- der of putamen, cerebellar atrophy, high signal in the middle cerebellar peduncles, cross sign in the pons. Conclusion： MSA is a neurodegenerative disease with complex symptoms, involved in multiple systems. The diagnosis of MSA needs detailed medical history, neurological examination and assistant methods like MRI.
出处
《河南医学研究》
CAS
2014年第1期120-122,共3页
Henan Medical Research
