期刊文献+

血小板活化因子与冠状动脉病变支数相关性研究 被引量:3

Correlation between platelet-activating factor and the number of stenosed coronary vessels
暂未订购
导出
摘要 目的:探讨冠脉造影患者血小板活化因子(platelet-activating factor,PAF)水平与冠状动脉病变支数的相关性。方法:将128例可疑冠心病患者按冠脉造影结果分为:健康对照组(21例)、冠心病组(107例)。冠心病组记录冠脉病变支数。用酶联免疫法(ELASA)测量血浆PAF浓度,分析其与冠状动脉病变支数的相关性。结果:PAF浓度与冠状动脉病变支数呈正相关,差异有统计学意义(P<0.05)。结论:PAF浓度水平有望作为冠心病病情监测的指标。 Objective: To investigate the correlation between platelet-activating factor(PAF) and the number of stenosed coronary vessels in patients with coronary angiography ( CAG). Methods : 128 cases with suspected CHD were divided into groups according to coronary angiography, including 21 normal cases, 107 patients with CHD, whose number of stenosed coronary vessels was recorded. The PAF concentrations were detected by ELISA, and the relationship between PAF concentrations and the number of stenosed coronary vessels was analyzed. Results: There were positive correlations between the PAF levels and the number of stenosed coronary vessels, the differences were statistically significant (P 〈 0. 05 ). Conclusion : PAF concentrations are related with the degree of coronary artery stenosis and may serve as an available index for the severity of CHD.
出处 《河南医学研究》 CAS 2014年第1期19-21,共3页 Henan Medical Research
关键词 冠心病 冠状动脉狭窄 血小板活化因子 冠脉造影 coronary disease coronary stenosis platelet-activating factor coronary angiography
  • 相关文献

参考文献12

  • 1Shih C H,Ozawa S,Ando N. Vascular endothelial growth factor expression predicts outcome and lymph node metastasis in squamous cell carcinoma of the esophagus[J].{H}Clinical Cancer Research,2000,(3):1161-1168.
  • 2Vadas P,Gold M,Perelman B. Platelet-activating factor,PAF acetylhydrolase,and severe anaphylaxis[J].{H}New England Journal of Medicine,2008,(1):28-35.
  • 3Libby P,Ridker P M,Maseri A. Inflammation and atherosclerosis[J].{H}CIRCULATION,2002,(9):1135-1143.
  • 4Pendurthi U R,Meng F,Mackman N. Mechanism of resveratrol-mediated suppression of tissue factor gene expression[J].{H}Biomedical Research,2002,(1):155-162.
  • 5Owen J S,Thomas M J,Wykle R L. Platelet-activating factor[J].{H}Methods in Enzymology,2007,(434):105-116.
  • 6Stafforini D M. Biology of platelet-activating factor acetylhydrolase (PAF-AH,lipoprotein associated phospholipase A2)[J].{H}Cardiovascular Drugs and Therapy,2009,(1):73-83.
  • 7Gawaz M,Langer H,May A E. Platelets in inflammation and atherogenesis[J].{H}Journal of Clinical Investigation,2005,(12):3378-3384.
  • 8Melnikova V,Bar-Eli M. Inflammation and melanoma growth and metastasis:the role of platelet-activating factor (PAF) and its receptor[J].{H}Cancer and Metastasis Reviews,2007,(3-4):359-371.
  • 9Davì G,Patrono C. Platelet activation and atherothrombosis[J].{H}New England Journal of Medicine,2007,(24):2482-2494.
  • 10Lievens D,yon Hundelshausen P. Platelets in atherosclerosis[J].{H}Thrombosis and Haemostasis,2011,(5):827.

同被引文献26

引证文献3

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部