摘要
随着酒精性肝病(ALD)发病率逐年增长,对人类健康和社会发展构成严重威胁,因此,在全世界范围内受到普遍关注。ALD的发病机制非常复杂,以往主要集中在乙醇代谢过程引起氧化应激和谷胱甘肽耗竭、营养不良、内毒素激活枯否细胞而引起相关炎症上。最新研究发现,脂代谢、肝再生和凋亡、肝脏抗氧化等多种信号转导通路、肠道菌群紊乱、细胞因子、免疫反应等多种因素参与ALD的发生发展。因此,本文将目前有关ALD最新研究进展结合国内外自然病程研究、流行现状和其它影响因素,对ALD发病机制作一综述。
With the increases of incidence year by year,alcohol-ic liver disease(ALl)constitutes a serious threat to human health and social development.Thus,it has been always a world-concerned disease.The pathogenesis of ALD ivery s com-plex.Early research on the pathogenesis of ALD mainly focused on the related inflammations caused by malnutrition,endotoxin-activated kupffer cells and the inflammations are also caused by oxidative stress and glutathione depletion in metabolic process ofethanol.However,it is discovered from recent studies that the intestinal flora disturbance,cytokines,immune response and muhiple signal transduction pathways such as lipid metabolism,liver regeneration and apoptosis and antioxidant in liver are some of the factors involved in the development of ALD.This article presents the latest research on pathogenesis of ALD.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2014年第2期160-163,共4页
Chinese Pharmacological Bulletin
基金
江苏高校优势学科建设工程资助项目(No ysxk-2010)
关键词
酒精性肝病
氧化应激
脂质过氧化
肠源性内毒素血症
炎症
发病机制
alcohol liver disease
oxidative stress
lipid peroxi-dation
intestinal endotoxemia
inflammation
pathogenesis
