摘要
目的探讨孕期补锌对孕妇及胎儿的汞毒性的拮抗作用及其抗氧化损伤机制。方法根据孕中、晚期孕妇的血汞值选取病例组、治疗组和对照组,每组30例。比较3组孕妇的血汞、血锌水平以及新生儿生长发育指标;应用脂质过氧化试剂盒检测3组胎盘的谷胱甘肽过氧化物酶(GSH-PX)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和丙二醛(MDA)表达水平。结果治疗组孕晚期母血中汞质量浓度显著低于病例组,锌质量浓度高于病例组,差异均有统计学意义(P<0.05);治疗组孕晚期母血中汞质量浓度低于孕中期,锌质量浓度高于孕中期,差异也均有统计学意义(P<0.05)。治疗组新生儿的头围、身长、出生体质量优于病例组,差异均有统计学意义(P<0.05)。治疗组胎盘的GSH-PX、SOD和CAT活性高于病例组,但低于正常组;治疗组胎盘的MDA含量低于病例组,但高于正常组,差异均有统计学意义(P<0.05)。结论孕期补锌可拮抗汞对孕妇及胎儿的毒性作用,锌的抗氧化损伤作用是其重要机制之一。
Objective To investigate the antagonism of zinc to mercury caused toxicity in mothers and fetuses and its anti- oxidation mechanism. Methods According to the levels of maternal blood mercury at middle and late pregnancy, 90 pregnant women were divided equally into the case group, the treatment group, and the control group. The levels of maternal blood mercury and zinc, and neonatal growth and development indexes of three groups were compared. The levels of glutathione peroxidase （GSH-PX）, superoxidase dismutase （SOD）, catalase （CAT）, and malondialdehyde （MDA） in placenta were detected by lipid peroxidation kit. Results The level of maternal blood mercury at late pregnancy of the treatment group was lower than that of the case group, while the level of zinc was higher than that of the case group and the difference was statistically significant （P 〈 0.05）. The level of maternal blood mercury of the treatment group at late pregnancy was lower than that at middle pregnancy, while the level of zinc was higher than that at middle pregnancy and the difference was also statistically significant （ P 〈 0.05）. The head circumference, crown-heel length, and birth weight of neonates of the case group were significantly lower than those of the treatment group in which the data were better （ P 〈 0.05）. The levels of GSH-PX, SOD, and CAT in placenta of the treatment group were higher than those of the case group, but lower than those of the control group. The level of MDA in placenta of the treatment group was lower than that of the case group, but higher than that of the control group, and the differences were statistically significant （P 〈 0.05）. Conclusion Zinc supplement during pregnancy can antagonize mercury caused toxicity in mothers and fetuses. Antioxidant effect of zinc may be one of the important mechanisms.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2014年第2期193-196,200,共5页
Journal of Shanghai Jiao tong University:Medical Science
