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骨肉瘤转移的相关分子及临床应用研究进展 被引量：11

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摘要 为了提高骨肉瘤患者的生存间期及生活质量，需要最终解决以下几个问题：为什么骨肉瘤会发生转移，尤其是转移到肺上？重要的是为什么肺转移的骨肉瘤患者对化学治疗不敏感？研究发现，发生肺转移的骨肉瘤细胞表现出了和原发性肿瘤细胞完全不同的生物学特性。研究发现，发生转移后的肿瘤细胞群在细胞倍增速度、酶表达谱、染色体组型和化疗药物的敏感性方面都不同于其原发的肿瘤细胞群。这就解释清楚了对原发肿瘤有效的化疗方案，为什么却对转移性肿瘤丝毫不起作用。
作者 赵海恩 赵新文 周勇 杨彤涛
机构地区 第四军医大学唐都医院
出处 《中国矫形外科杂志》 CAS CSCD 北大核心 2014年第5期434-440,共7页 Orthopedic Journal of China
关键词 骨肉瘤转移 免疫监视 失巢凋亡 休眠细胞学说
分类号 R738.1 [医药卫生—肿瘤]
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参考文献31

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同被引文献109

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中国矫形外科杂志
2014年 第5期

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