摘要
目的观察经验方肾衰Ⅰ号与治则相同的归肾经药物方对慢性肾衰竭模型的疗效比较。方法将动物分为造模组与假手术组.造模组动物用5/6肾切除方法建立大鼠慢性肾衰竭模型。将造模组动物再分为模型组、不归肾经方组、经验方肾衰Ⅰ号组和归肾经方组。2月后开始治疗。连续治疗2月后,禁食12h,麻醉后腹主动脉采血检测肾功能及血色素等指标。结果造模2月后,与假手术组比较,造模组动物体重(BW)、血浆总蛋白(Tp)、血蛋白(ALB)、血色素(Hb)显著降低(P<0.05),血液中血尿素氮(BUN)、肌酐(Cr)含量显著增高(P<0.01);治疗2月后,与假手术组比较,模型组BW、Tp、ALB、Hb含量显著降低(P<0.01),BUN、Cr含量显著增高(P<0.01);与模型组比较,各治疗组BW显著增高(P<0.01)、BUN显著降低(P<0.01);归肾经方组Hb、Tp含量显著高于不归肾经方组和经验方组(P<0.01),3治疗组之间BW、ALB、BUN及Cr含量之间没有差异(P>0.05)。结论归肾经方对肾功能的保护作用与经验方、不归肾经方没有差异,但在改善营养和贫血状况方面优于以上方证治疗2组。
Objective To investigate different effect on chronic renal failure rat model with proved prescription and prescription com- posed of medicines which belong to kidney meridian and have the same therapeutic method. Methods Building up the chronic kidney model with 5/6 kidney excision. 2 months later, rats were treated with these medicines： group A （prescription made of medicines which don＇t be- long to kidney meridian but have the same therapeutic effect）, group B （prescription made of medicines which belong to kidney meridian but have the same therapeutic effect）, group C （proved prescription）. After 2 month continued therapy, we collected blood from abdnominal aorta for testing kidney function and hemoglobin etc. Results After 2 months, compared with sham operated control, level of weight, Tp, ALB and HB content in the blood on operated group are significantly reduced （P 〈 0.05 ） ; level of BUN and Cr are marked elevated（P 〈 0. O1 ）. After 2 month treating, compared with sham operated control,level of weight, Tp, ALB and HB content in the blood on model showed signifi- cantly decreased and level of BUN and Cr markedly increased. Compared with model group, the weight increased and BUN level decreased （P 〈0.01 ） in other groups. Level of Hb and Tp in group C are higher than those in group B and A. There are no marked difference in weight, ALB and BUN level among the three treat groups （P 〉 0.05）. Conclusion On protection of kidney function, description composed of medicines belonged to kidney makes no difference with proved description and description consist of medicines not belonged to kidney, but it is better in improving nutrition and anemia than the other groups.
出处
《湖北中医药大学学报》
2014年第1期10-12,共3页
Journal of Hubei University of Chinese Medicine
基金
2010年全国名老中医药专家传承工作室建设项目(国中医药人教发2010-59)
关键词
中医辨证
中药归经
慢性肾衰竭
动物模型
Syndrome differentiation, Meridian of traditional Chinese medicine, chronic renal failure, animal model, rat
