摘要
目的探讨丝裂霉素C和羟基喜树碱灌注治疗膀胱肿瘤切除患者的临床效益,为治疗膀胱肿瘤积累经验。方法选取2007年4月至2013年2月收治的膀胱肿瘤切除患者48例,采用随机数字表法分为观察组和对照组,每组24例。对照组患者采取丝裂霉素C灌注治疗,观察组患者采取羟基喜树碱灌注治疗,比较两组患者2年内复发率、不良反应发生率以及成本和效果情况。结果观察组患者术后2年复发率为12.5%,对照组为25.0%,差异有统计学意义(P<0.05)。观察组患者不良反应发生率低于对照组,差异有统计学意义(P<0.05)。观察组成本效果比值高于对照组,差异无统计学意义(P>0.05)。结论膀胱癌患者术后采取羟基喜树碱灌注治疗方案的成本和效果优于丝裂霉素C灌注治疗方案。羟基喜树碱灌注治疗方案临床效果较佳,值得进一步推广。
Objective To explore the clinical effects of two different chemotherapy drugs on blad- der tumor resected patient, and accumulate experience of treatment for the disease. Methods 48 cases of bladder tumor were collected in this study from April 2007 to February 2013, and divided into study group and control group by using the method of random digits table, 24 cases in each group. Patients in the control group were treated with mitomycin C, and patients in the research group were treated by hydroxycamptothe- cin peffusion therapy. Recurrence rate within 2 years, the incidence of adverse reactions, and the rate of effect and cost were compared between patients from two groups. Results The 2 year recurrence rate was 12. 5% and 25% in the study group and control group respectively, the difference was statistically signifi- cant（ P 〈0. 05 ）. The incidence of adverse reaction in study group was lower than that in the control group, and the difference was statistically significant（ P 〈 0. 05 ）. The rate of effect and cost in the study group was higher than that in the control group, the difference was not statistically significant （ P 〉 0. 05 ）. Conclu- sions Hydroxycamptothecin showed better clinical effects and cost than Mitomycin C when treating bladder resection patients, and was worth for further application.
出处
《中国肿瘤临床与康复》
2014年第2期215-217,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
丝裂霉素C
羟基喜树碱
复发率
不良反应
成本效果比
Mitomycin C
Hydroxycamptothecin
Recurrence rate
Adverse reaction
Rate of cost and effect
