摘要
目前,肿瘤是人类疾病的头号死因,尽管其死亡率在过去几十年间一直在下降,但下降幅度仅为10%,与曾经的高死亡率疾病(如鼠疫、天花、流行性感冒和肺结核)相比微不足道。因此,战胜肿瘤还有很长的路要走。大量的研究表明,炎症与肿瘤似乎是一对相生相伴的疾病,炎性微环境因素及其影响日益受到研究者的重视,很可能为攻克肿瘤治疗难题提供全新的思路。本文综述了炎症在肿瘤的产生、发展、转移中的作用以及靶向炎症相关因子治疗肿瘤的研究进展。
Cancer is the leading cause of death. Although the mortality is decreasing in the past decades, the decline is just 10%, which is negligible in comparison to those highly-lethal disease such as plague, smallpox, influenza and pulmonary tuberculosis. Therefore, much more time is needed to defeat cancer. Numerous studies show tight relationship between inflammation and tumorigenesis. The role of inflammatory microenvironment in tumor development is becoming a hotspot in the field of cancer research. This review focuses on the role of inflammation in various stages of tumorigenesis and proinflammatory factor-targeted cancer therapy.
出处
《国际药学研究杂志》
CAS
CSCD
2014年第1期63-67,74,共6页
Journal of International Pharmaceutical Research
基金
国家自然科学基金资助项目(81272320)
北京市自然科学基金资助项目(7132151)
关键词
炎症
肿瘤
炎性细胞因子
肿瘤治疗
inflammation
neoplasmas
proinflammatory cytokine
cancer therapy
