1Kivipelto M, Helkala EL, Laakso MP, et al. Midlife vasclllar risk factors and Alzheimer's disease in later life: longitudinal, population based study[ J]. Brit Med J,2001,322(7300) :1447 -1451.
2Kivipeho M, Helkala EL, Laakso MP, et al. Apolipoprot~in E epsilon 4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for latelife Alzheimer dis- ease[ J]. Ann Intern Med ,2002,137 ( 3 ) : 149 - 155.
8Goate A, Chartie2HarlinM C, Mullan M, et al. Segrega2 tion of a mis- sense mutation in the amyloid precursor protein gene with familia IA lzheime r's disease[ J ]. Na ture,1991,349 :704 -706.
9Bird TD. Genetic factors in Alzheimer's disease [ J ]. N Engl J Med, 2005,352(5) :862 -864.
10Bertram L,McQueen M B,Mullin K,e t al. Systematic me ta2ana lyses ofA lzhe imer disease gene tic association stud2 ie s:the A lzGene da tabase[ J ]. Nat Gene t,2007,39 : 17 - 23.
