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迷迭香酸对新生大鼠海马星形胶质细胞增殖的影响及其机制探讨 被引量：3

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摘要 目的观察迷迭香酸(RA)对新生大鼠海马星形胶质细胞增殖的影响,并探讨其机制。方法取原代培养的新生大鼠海马星形胶质细胞,处理组加入1、5、10、20、40μg/mL的RA处理,对照组加相同体积的DMEM。免疫组化细胞染色法计数BrdU阳性细胞数(细胞增殖),WST-1法检测波长450 nm时的OD值(细胞活力),ELISA法检测细胞培养液上清的脑源性神经营养因子(BDNF)。结果作用72 h,20、40μg/mL的RA处理组BrdU阳性细胞数高于对照组及其他浓度RA处理组(P均<0.05),20μg/mL的RA处理组波长450 nm下的OD值、BDNF均高于对照组及其他浓度RA处理组(P均<0.05);其余各组两两比较,P均>0.05。结论一定剂量的RA可促进新生大鼠海马星形胶质细胞增殖,该作用与其提高细胞活力、促进BDNF释放有关。
作者 晋翔 刘鹏 张雅红
机构地区 海军总医院 西京医院
出处 《山东医药》 CAS 2014年第8期25-26,I0002,共3页 Shandong Medical Journal
关键词 抑郁症 迷迭香酸 星形胶质细胞 增殖 脑源性神经营养因子 大鼠
分类号 R749.92 [医药卫生—神经病学与精神病学]
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参考文献11

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二级参考文献33

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共引文献31

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二级引证文献59

山东医药
2014年 第8期

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