摘要
目的:观察抗焦虑抑郁药联合质子泵抑制剂治疗伴有焦虑和(或)抑郁的难治性反流性食管炎(RRE)患者的疗效。方法:将123例RRE伴焦虑和(或)抑郁状态的患者随机双盲分为试验组(65例)与对照组(58例)。两组患者均给予质子泵抑制剂(埃索美拉唑镁肠溶片)40 mg,qd;试验组加服抗焦虑抑郁药(氟哌噻吨美利曲辛)1片,bid;对照组加服安慰剂1片,bid,疗程4周。比较两组治疗前后临床症状、焦虑抑郁状况及胃镜下分级。结果:治疗4周后,试验组与对照组的症状总有效率分别为81.54%、10.34%(P<0.01);试验组焦虑(t=-10.69)、抑郁(t=-12.57)情况较对照组改善明显,两组差异有统计学意义(P<0.01);两组在胃镜下分级差异无统计学意义(P>0.05)。结论:抗焦虑抑郁药联合质子泵抑制剂治疗RRE可明显改善患者症状及焦虑和(或)抑郁状态,并明显缓解反流性食管炎的临床症状。
OBJECTIVE： To investigate the anti-anxiety and depression drug combined with PPI in the treatment of refractory reflux esophagitis （RRE） complicating with anxiety and （or） depression. METHODS： 123 cases of RRE complicating with anxiety and （or） depression were randomly divided into trial group （65 cases） and control group （58 cases）. Both groups were given Esomeprazole magnesium enteric-coated tablets 40 mg, once a day; trial group was additionally given one piece of anxiety depres- sion drug （flupentixol melitracen）, twice a day ; control group was additionally given one piece of placebo twice day for 4 weeks. The clinical symptom, the degree of anxiety depression and gastroscopic scaling were compared between 2 groups before and after treatment. RESULTS： After 4 weeks of treatment, the total effective rates of experimental group was 81.54% and that of control group was 10.34%; there was statistical significance （P〈0.01）. The anxiety （t=-10.69） and depression （t=-12.57） of trial group were improved significantly, compared with control group; there was statistical significance （P〈0.01）. There was no statisti-＂ cal significance in gastroscopic scaling between 2 groups （P〉0.05）. CONCLUSIONS. PPI combined with anti-anxiety depression drug can improve patients＇ anxiety and depression status, and release the symptom of RE in the treatment of RRE.
出处
《中国药房》
CAS
CSCD
2014年第10期910-912,共3页
China Pharmacy
关键词
抗焦虑抑郁药
难治性反流性食管炎
质子泵抑制剂
疗效
Anti-anxiety and depression drug
Refractory reflux esophagitis
PPI
Therapeutic efficacy
