摘要
以泊洛沙姆407(P407)和188(P188)为载体材料,采用冷溶法将促孕灌注液制成原位凝胶,考察了P407和P188浓度、羟丙基甲基纤维素浓度(HPMC)、海藻酸钠浓度及促孕灌注液对胶凝温度的影响,研究了体外溶蚀、体外释药特性.结果表明,P407浓度为18%(w)、P188浓度为7.5%(w)、HPMC浓度为0.3%(w)时,凝胶平均胶凝温度为27.9℃,6 h内平均体外累积溶蚀度和药物累积释放度分别为92.11%和95.42%,凝胶中的药物成分主要通过溶蚀方式释放,药物释放符合零级释药方程.
Fertility-promoting intrauterine infusion in situ gel （FPG） was prepared by cold soluble method with Poloxamer 407 （P407） and Poloxamer 188 （P188）. The effects of concentrations of P407, P 188, hydroxy propyl methyl cellulose （HPMC） and sodium alginate on gelation temperature were studied, the gelation temperature of in situ gel before and after addition of fertility-promoting intrauterine infusion liquid and release behavior in vitro were investigated. The results showed that the average gelation temperature of FPG was 27.9℃ when the concentrations of P407, P188 and HPMC were 18%（ω）, 7.5%（ω） and 0.3%（ω）. Average accumulated loss rate of gel and accumulated release rate of drug were 92.11% and 95.42% in 6 h. The drug in the gel was released by the gel erosion, and the release profiles accorded to zero order equation.
出处
《过程工程学报》
CAS
CSCD
北大核心
2014年第1期139-144,共6页
The Chinese Journal of Process Engineering
基金
四川农业大学"优秀硕士论文培育基金"项目
关键词
促孕灌注液
原位凝胶
胶凝温度
体外溶蚀
体外释放
淫羊藿苷
fertility-promoting intrauterine infusion liquid
in situ gel
gelation temperature
in vitro dissolution
in vitro release
icariin
