心肌肌钙蛋白I、肌钙蛋白T、肌酸激酶同工酶MB早期诊断急性心肌梗死敏感性及特异性比较分析被引量：20

Clinical comparison of the sensitivity and specificity of cardiac troponin I and cardiac troponin T and creatine kinase MB for the early diagnosis of acute myocardial infarction

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摘要目的探讨心肌肌钙蛋白 I(c Tn I)、肌钙蛋白 T(c Tn T)及肌酸激酶同工酶 MB(CK-MB)早期诊断急性心肌梗死的临床应用价值。方法对 6 0例急性心肌梗死 (AMI)和 40例不稳定型心绞痛 (UA)患者的同一血样标本检测 c Tn I、c Tn T、CK-MB 3项指标 ,分别进行两组间比较 ,并对 AMI组和 UA组各指标作对比分析。结果 c Tn I、c Tn T早期诊断急性心肌梗死灵敏度高于 CK-MB,阳性率分别为6 3.3%、46 .7%、18.3% ,P<0 .0 1;c Tn I和 c Tn T无显著差别 ,P>0 .0 5 ;c Tn I、c Tn T、CK-MB特异性相当 ,无显著差异。结论心肌肌钙蛋白 I和肌钙蛋白 T对于 AMI的早期诊断具有较高灵敏度和较强特异性 ,是心肌损伤特异性标志物 ,c Tn I检测方便、快捷、准确。 Objective To observe the application value of cardiac troponin I (cTnI),cardiac troponin T (cTnT) and creatine kinase MB (CK MB) for the early diagnosis of acute myocardial infarction (AMI).Methods The same serum sample was measured to detect the indexes of cTnI,cTnT and CK MB levels in 60 patients with AMI and 40 patients with UA.Comparison between AMI and UA was performed and all the indexes were analysed contrastively.Results The sensitivity of cTnI and cTnT was higher than that of CK MB,and their positive rates were 63.3%,46.7% and 18.3% respectively (P<0.01).There was no significant difference between cTnI and cTnI (P>0.05) and the specificity of the three indexes were almost the same without significant difference.Conclusion cTnI and cTnT,as specific markers of cardiac damage,are more sensitive and specific in the early diagnosis of AMI.As a convenient,swift and accurate measurement method,cTnI has significant clinical value.

作者左鹰贾瑞珍

机构地区北京市急救中心北京市铁道部铁路总医院

出处《中国综合临床》北大核心 2001年第2期97-98,共2页 Clinical Medicine of China

基金北京市卫生局青年科学基金项目

关键词急性心肌梗死心肌肌钙蛋白Ⅰ 肌钙蛋白T 肌酸激 Myocardial infarction Cardiac troponin I Cardiac troponin T Creative kinase MB DiagnosiT

分类号 R542.22 [医药卫生—心血管疾病]

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