摘要
为探讨非清髓性异基因外周血造血干细胞移植 (NAPBSCT)在治疗重症再生障碍性贫血 (SAA)中的作用 ,4例HLA完全相合的重症再生障碍性贫血病人 (2例肝炎相关性重症再生障碍性贫血 ,2例重症再生障碍性贫血 )接受了NAPBSCT ,结果 4例均顺利度过造血抑制期并移植成功 (完全性植入 3例 ,嵌和性植入 1例 ) ,外周血象及骨髓造血功能快速恢复正常。 4例均无急性移植物抗宿主病和间质性肺炎等并发症。本结果初步表明 :NAPBSCT简单、安全、并发症轻、造血功能重建快 ,为SAA的治疗开辟了一条新途径。
In order to investigate the use of nonmyeloablative allogeneic peripheral blood cell transplantation for severe aplastic anemia , four patients were studied ,among them two cases were complicated by hepatitis. All of four cases received allogeneic peripheral blood stem cell transplantation from HLA identical siblings after a nonmyloabalative conditioning . All of four patients were engrafted of donor cell (three with full donor cell grafting , one with mixed chimerism ) and hematopoiesis recovered rapidly (WBC recovered to more than 0.5×10 9 /L during +9d～+12d and platelet recovered to more than 30×10 9 /L during +10d～+15d). None of them developed severe aGVHD or interstitial pneumonia .These findings indicate that the procedure is much safer and more effective and with less complications than the myeloablative conditioning regimens, and may represent another new approach in the management of patients with severe aplastic anemia .
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2001年第1期5-7,共3页
Medical Journal of Chinese People's Liberation Army
