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非清髓异基因造血干细胞移植——造血干细胞移植的新方向 被引量：11

NONMYELOABLATIVE ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION——A NEW WAY FOR BLOOD STEM CELL TRANSPLANTATION
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摘要 简述了国内外刚刚开展的非清髓异基因造血干细胞移植 (NAST)的主要研究进展和研究方向。对NAST的概念、预处理方案、移植物抗宿主病预防、移植物抗白血病效应及临床应用等问题作了讨论和介绍。并提出NAST是对传统异基因造血干细胞移植理论和观念的发展及更新 ,为血液病、恶性肿瘤及免疫、遗传性疾病的治疗开辟了新路径。并建议加强对NAST有关问题的协作研究。 The author briefs the main research progress and way of the new developed nonmyeloablative allogeneic stem cell transplantation(NAST).The definition,conditioning regimen ,graft versus host disease(GVHD),graft versus leukemia(GVL) effects and clinical research are disussed.NAST is developed from theories and ideas of tranditional allogeneic stem cell transplantation,is a new way for hematological diseases ,malignant tumors and congenital immunodeficiencies.The author proposes cooperative researches on problems related with NAST.
作者 艾辉胜
机构地区 军事医学科学院附属医院
出处 《解放军医学杂志》 CAS CSCD 北大核心 2001年第1期1-4,共4页 Medical Journal of Chinese People's Liberation Army
关键词 预处理 非清髓性异基因造血干细胞移植 NAST nonmyeloablative conditioning regimen allogeneic stem cell transplantation
分类号 R457 [医药卫生—治疗学]
  • 相关文献

参考文献12

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  • 2[2]Champlin R, Khouri I, Kornblau S et al. Reinventing bone marrow transplantation: reducing toxicity using nonmyeloablative, preparative regimens and induction of graft-versus-malignancy. Curr Opin Oncol, 1999, 11(2): 87
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同被引文献82

  • 1孙玲,汝文华.造血干细胞移植患者极期口腔护理[J].临床护理杂志,2003,2(3):12-14. 被引量：15
  • 2熊辉霞,陈宝安,丁家华,孙雪梅,赵刚,王骏,高冲,孙耘玉,程坚,董伟民.非清髓异基因外周造血干细胞移植治疗难治性恶性血液病[J].临床肿瘤学杂志,2005,10(1):14-17. 被引量：2
  • 3达万明 裴雪涛.外周血干细胞移植[M].北京:人民卫生出版社,2001.112-113,118.
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  • 5[2]Brown R A, Adkins L T, Goodnough L T,et al. Factors that influence the collection and engraftment of allogeneic peripheral-blood stem cells in patients with hematologic malignancies[J].J Clin Oncol,1997,15(9):3 067～3 074 .
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  • 7[6]Slavin S,Nagler A, Naparstek E,et al. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases[J]. Blood,1998,91(3):757-763.
  • 8[7]Sykes M, Saches D H, Spitzer T R. Mixed chimerism followed by DLI for lymphohematoietic GVHreactions without GVHD: from animal models to patients[J]. Hematology,1999,(American Society of Hematology Education Program Book):405.
  • 9[9]Champlin R. Nonmyeloablative chemotherapy with allogeneic hematopoietic transplantation as adoptive immunotherapy for malignancies[A]. In: Schechter GP, Hoffman R, Schrier SL(eds). Hematology[M]. Washington:The ASH education program book,1999.405-412.
  • 10[10]To L B, Haylock D N, Simmons P J,et al.The biology and clinica uses of blood stem cells[J]. Blood,1997,89(7):2 233

引证文献11

二级引证文献28

解放军医学杂志
2001年 第1期

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