摘要
目的观察桔梗、牛膝不同配伍的血府逐瘀汤对大鼠不同脏器中环核苷酸水平的影响。方法采用ELISA法,观察桔梗、牛膝不同配伍的血府逐瘀汤对血瘀证模型大鼠各脏器组织中cAMP、cGMP含量及cAMP/cGMP比值的影响。结果含桔梗的用药组心脏组织中cAMP、cGMP水平明显降低,含牛膝的用药组肝脏组织中cAMP水平明显降低,cGMP在肾脏中的分布增加。结论桔梗确有"载药上行"之功,能增加药物在心肺中的分布;而牛膝确有"引药下行"之功,能增加药物在肝肾中的分布。
Objective： To study the concerted application mechanisms of Platycodon grandiforus and Achyran- thes bidentataon in Xuefu Zhuyu Decoction（XZD）,the Influnce of XZD on adhesion molecules in Cyclic Nucleo- side in different organs of blood stasis rats. Methods： Adopt the method of ELISA,Expression of cAMP,cGMP, cAMP/eGMP in different organs of blood stasis rats receiving different concerted application of Platyeodon grandi- forus and Achyranthes bidentataon in XZD was observed. Results： The experiment confirmed that the ＂guided rugs up＂ action of Platycodon grandiflorum and the ＂guided rugs down＂ action of Achyranthes bidentaton was ex- isted objectively.
出处
《中国中医急症》
2014年第2期235-237,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
江苏省中医药管理局资助项目(LZ09014)
关键词
引经药
桔梗
牛膝
血府逐瘀汤
环核苷酸
Channel ushering drug
Platycodon grandiforum
Achyranthes bidentataon
Xuefu Zhuyu Decoction
Cyclic Nucleoside
