摘要
膀胱癌是常见的恶性肿瘤,绝大多数为非肌层浸润性膀胱癌。目前,传统的治疗方法仍不能治愈所有膀胱癌患者,膀胱内灌注化疗药物和免疫制剂治疗后失败的膀胱癌缺乏有效的治疗方法。近年来,溶瘤腺病毒治疗肿瘤的研究大量报道,膀胱癌由于给药方便、局部给药不会引起全身毒副作用而成为溶瘤腺病毒治疗的理想癌种。全文综述溶瘤腺病毒膀胱内灌注治疗膀胱癌的研究进展。
Bladder cancer is a common malignancy. Most patients with bladder cancer are non-mus- cle invasion at initial diagnosis. At present, no therapy can cure all the patients with bladder cancer. Recently,oncolytic adenovirus therapies for tumor have been reported. Bladder cancer is an ideal target for viral therapy because viruses can be directly delivered, thus providing contact with the tu- mor and minimal dissemination to other sites. The advances of intravesical infusion therapy with on- colytic adenovirus for bladder cancer were reviewed in this article.
出处
《中国肿瘤》
CAS
2014年第2期148-152,共5页
China Cancer
基金
浙江省钱江人才计划项目(2009R10001)
关键词
膀胱癌
溶瘤腺病毒
膀胱灌注
bladder cancer
oncolytic adenovirus
intravesical infusion therapy
